中华普通外科杂志
中華普通外科雜誌
중화보통외과잡지
CHINESE JOURNAL OF GENERAL SURGERY
2014年
12期
945-949
,共5页
张燕娜%孙强%周易冬%茅枫%关竞红%王常珺
張燕娜%孫彊%週易鼕%茅楓%關競紅%王常珺
장연나%손강%주역동%모풍%관경홍%왕상군
乳腺肿瘤%雌激素受体β%肿瘤分期
乳腺腫瘤%雌激素受體β%腫瘤分期
유선종류%자격소수체β%종류분기
Breast neoplasms%Estrogen receptor β%Neoplasm staging
目的 探讨雌激素受体β表达与不同分期及分型浸润性乳腺癌的关系. 方法 回顾性分析446例浸润性乳腺癌患者的临床病理资料,分析其与雌激素受体β的相关性.结果 在446例浸润性乳腺癌中,328例ERβ表达阳性(73.5％).在ERα+组及ERα-组,ERβ的阳性表达率分别为77.9％ (240/308)和63.8％ (88/138).ERβ的表达与ERα(P ＜0.01)表达呈正相关;与PR、组织学分级、HER-2及Ki-67表达无明确相关性(均P＞0.05).ERβ表达在不同年龄、肿瘤最大径及淋巴结转移组中的差异无统计学意义(均P ＞0.05).418例乳腺癌进入分期及NPI评分分析,不同分期及NPI评分在ERβ+及ERβ-两组之间分布差异无统计学意义(分期:P=0.743;NPI:P=0.644).Luminal A亚型、Luminal B1亚型、Luminal B2亚型、HER-2亚型及TN亚型中ERβ阳性率分别为75.6％ (88/118)、75.9％(110/145)、85.2％ (46/54)、68.4％(39/57)及62.5％(45/72).在不同分型乳腺癌中,Luminal型(LA、LB1及LB2)与非Luminal型(HER-2及TN)之间,ERβ的表达差异有统计学意义(P =0.007).结论 ERβ表达与肿瘤分期、NPI评分不相关,而与肿瘤Luminal分型相关.
目的 探討雌激素受體β錶達與不同分期及分型浸潤性乳腺癌的關繫. 方法 迴顧性分析446例浸潤性乳腺癌患者的臨床病理資料,分析其與雌激素受體β的相關性.結果 在446例浸潤性乳腺癌中,328例ERβ錶達暘性(73.5％).在ERα+組及ERα-組,ERβ的暘性錶達率分彆為77.9％ (240/308)和63.8％ (88/138).ERβ的錶達與ERα(P ＜0.01)錶達呈正相關;與PR、組織學分級、HER-2及Ki-67錶達無明確相關性(均P＞0.05).ERβ錶達在不同年齡、腫瘤最大徑及淋巴結轉移組中的差異無統計學意義(均P ＞0.05).418例乳腺癌進入分期及NPI評分分析,不同分期及NPI評分在ERβ+及ERβ-兩組之間分佈差異無統計學意義(分期:P=0.743;NPI:P=0.644).Luminal A亞型、Luminal B1亞型、Luminal B2亞型、HER-2亞型及TN亞型中ERβ暘性率分彆為75.6％ (88/118)、75.9％(110/145)、85.2％ (46/54)、68.4％(39/57)及62.5％(45/72).在不同分型乳腺癌中,Luminal型(LA、LB1及LB2)與非Luminal型(HER-2及TN)之間,ERβ的錶達差異有統計學意義(P =0.007).結論 ERβ錶達與腫瘤分期、NPI評分不相關,而與腫瘤Luminal分型相關.
목적 탐토자격소수체β표체여불동분기급분형침윤성유선암적관계. 방법 회고성분석446례침윤성유선암환자적림상병리자료,분석기여자격소수체β적상관성.결과 재446례침윤성유선암중,328례ERβ표체양성(73.5％).재ERα+조급ERα-조,ERβ적양성표체솔분별위77.9％ (240/308)화63.8％ (88/138).ERβ적표체여ERα(P ＜0.01)표체정정상관;여PR、조직학분급、HER-2급Ki-67표체무명학상관성(균P＞0.05).ERβ표체재불동년령、종류최대경급림파결전이조중적차이무통계학의의(균P ＞0.05).418례유선암진입분기급NPI평분분석,불동분기급NPI평분재ERβ+급ERβ-량조지간분포차이무통계학의의(분기:P=0.743;NPI:P=0.644).Luminal A아형、Luminal B1아형、Luminal B2아형、HER-2아형급TN아형중ERβ양성솔분별위75.6％ (88/118)、75.9％(110/145)、85.2％ (46/54)、68.4％(39/57)급62.5％(45/72).재불동분형유선암중,Luminal형(LA、LB1급LB2)여비Luminal형(HER-2급TN)지간,ERβ적표체차이유통계학의의(P =0.007).결론 ERβ표체여종류분기、NPI평분불상관,이여종류Luminal분형상관.
Objective To explore the association of estrogen receptor β expression with different stages and molecular subtypes of invasive breast cancer.Methods The clinicopathologic data of 446 invasive breast cancer cases was retrospectively analyzed.ERβ expression was evaluated by types and stages.Results Of all 446 invasive breast cancer cases,328 (73.5％) were ERβ positive.The ERβ positive rate was 77.9％ (240/308) and 63.8％ (88/138) in ERα + group and ERα-group,respectively.The ERβ expression in breast cancer was positively correlated with ERα (P ＜ 0.01) while it had no correlation with PR,histological grade,HER-2 and Ki-67 (P ＞ 0.05).ERβ expression was not significantly different among different age,tumor size and axillary lymph node groups(all P ＞ 0.05).A total of 418 invasive breast cancer cases were recruited for pathologic stage and NPI analysis,including 168 cases at stage Ⅰ,152 cases at stage Ⅱ and 98 cases at stage Ⅲ.ERβ expression was not significantly different among different stages of breast cancer(P =0.743).Analyzed in these 418 cases,NPI was ＜ 3.4 in 126 cases,3.4-5.4 in 207 cases and ＞ 5.4 in 85 cases.ERβ expression was not significantly different among different NPI group (P =0.644).The ERβ positive rate in Luminal A subtype,Luminal B1 subtype,Luminal B2 subtype,HER-2 subtype and TN subtype was 75.6％ (88/118),75.9％ (110/145),85.2％ (46/54),68.4％ (39/57) and 62.5％ (45/72) respectively.ERβ expression was significantly different between Luminal subtype and non-Luminal subtype (P =0.007).Conclusions ERβ was not differentially expressed among different breast cancer stages and NPI groups.ERβ was differentially expressed in different breast cancer molecular subtypes.
