CAJ | 학술논문

目的：建立测定丹参素冰片酯中有机溶剂残留量的毛细管气相色谱法。方法采用顶空毛细管气相色谱法，N，N －二甲基甲酰胺为溶剂，DB － WAX 毛细管柱(30.0 m ×0.25 mm ×0.25μm)，氮气为载气，FID 检测器。结果乙醚、丙酮、四氢呋喃、乙酸乙酯、甲醇和乙醇6种有机溶剂均达到了完全分离，在考察的质量浓度范围内具有良好线性关系，最低检测限分别为6.48，5.33，4.79，7.43，12.87，4.81 ng，高、中、低3种质量浓度的回收率均大于98%。结论该方法灵敏度、准确度均达到有机溶剂残留量的检测要求，可用于丹参素冰片酯中6种残留溶剂的检测和分析。
목적：건립측정단삼소빙편지중유궤용제잔류량적모세관기상색보법。방법채용정공모세관기상색보법，N，N －이갑기갑선알위용제，DB － WAX 모세관주(30.0 m ×0.25 mm ×0.25μm)，담기위재기，FID 검측기。결과을미、병동、사경부남、을산을지、갑순화을순6충유궤용제균체도료완전분리，재고찰적질량농도범위내구유량호선성관계，최저검측한분별위6.48，5.33，4.79，7.43，12.87，4.81 ng，고、중、저3충질량농도적회수솔균대우98%。결론해방법령민도、준학도균체도유궤용제잔류량적검측요구，가용우단삼소빙편지중6충잔류용제적검측화분석。
Objective To develop a headspace capillary gC method for simultaneously determining the residual organic solvents in tan-shinol borneol ester. Methods The headspace capillary gC method was adopted with N, N - dimethylformamide as the solvent. N2 was used as the carrier gas. The organic solvents were separated on the DB - WAX capillary column(30. 0 m × 0. 25 mm × 0. 25 μm) with FID detector. Results The siX kinds of residual organic solvents ether, acetone, tetrahydrofuran, ethyl acetate, methanol and ethanol were completely separated an showed a good linearity during the investigated concentration range. Their lowest limit of detection in turn were 6. 48, 5. 33, 4. 79, 7. 43, 12. 87, 4. 81 ng, respectively. The average recovery rates of high, middle and low concentrations were all more than 98% . Conclusion The accuracy and sensitivity of this method all reach the detection requirement of residual organic solvents, which can be used for detecting and analyzing 6 kinds of residual organic solvents in tanshinol borneol ester.