CAJ | 학술논문

目的：观察神经节苷脂预防奥沙利铂致末梢神经毒性的疗效。方法将接受 FOLFOX6方案的患者随机分为3组，即神经节苷脂组、钙镁合剂组及单纯化疗组。利用奥沙利铂专用神经毒性分级标准观察其神经毒性发生率及严重程度。结果神经节苷脂组、钙镁合剂组及单纯化疗组急性神经毒性发生率分别为64.28%，66.67%，92.59%，差异有统计学意义（ P <0.05）。化疗4周期和8周期时3组慢性神经毒性发生率差异有统计学意义（ P <0.05）；神经节苷脂组和钙镁合剂组Ⅰ~Ⅲ度神经毒性均低于单纯化疗组（ P >0.05），神经节苷脂组和钙镁合剂组差异无统计学意义（ P >0.05）。结论应用神经节苷脂可有效预防或减少奥沙利铂神经毒性的发生率及损害程度。
목적：관찰신경절감지예방오사리박치말소신경독성적료효。방법장접수 FOLFOX6방안적환자수궤분위3조，즉신경절감지조、개미합제조급단순화료조。이용오사리박전용신경독성분급표준관찰기신경독성발생솔급엄중정도。결과신경절감지조、개미합제조급단순화료조급성신경독성발생솔분별위64.28%，66.67%，92.59%，차이유통계학의의（ P <0.05）。화료4주기화8주기시3조만성신경독성발생솔차이유통계학의의（ P <0.05）；신경절감지조화개미합제조Ⅰ~Ⅲ도신경독성균저우단순화료조（ P >0.05），신경절감지조화개미합제조차이무통계학의의（ P >0.05）。결론응용신경절감지가유효예방혹감소오사리박신경독성적발생솔급손해정도。
Objective To observe the effects of gangliosides for preventing the oXaliplatin induced peripheral neurotoXicity. Methods 85 patients with colorectal cancer treated by oXaliplatin + fluorouracil + calcium folinate chemotherapeutical regimen(FOLFOX) were randomly divided into the three groups of gangliosides, calcium and magnesium(Ca / mg) miXture and simple chemotherapy. According to the spe-cific nerve toXicity grading standard of oXaliplatin, the neurotoXicity incidence and severity of all patients were observed. Results The neurotoXicity incidences of the gangliosides group, the Ca / mg miXture group and the simple chemotherapy group were 64. 28% , 66. 67%and 92. 59% respectively, the differences among them were statistically significant( P < 0. 05) . There were statistically significant differ-ences in chronic neurotoXicity after 4 and 8 cycles of chemotherapy among the three groups( P < 0. 05) . The grade I - Ⅲ neurotoXicity in the Ca / mg miXture group and the gangliosides group were lower than that in the simple chemotherapy group( P > 0. 05 ), but the dif-ference between the Ca / mg miXture group and the gangliosides group had no statistical significance. Conclusion Using gangliosides can prevent the neurotoXicity occurrence effectively, and can decrease the incidence and the lesion degree of oXaliplatin induced neurotoXicity.