CAJ | 학술논문

目的：观察不同剂量阿托伐他汀治疗老年冠状动脉粥样硬化性心脏病的疗效及并发症。方法随机将128例老年冠心病患者分为试验组和对照组，每组64例。在常规治疗基础上，对照组口服阿托伐他汀15 mg /次；治疗组口服阿托伐他汀30 mg /次，两组服用阿托伐他汀均每天1次，疗程为5个月。比较两组治疗前后高密度脂蛋白胆固醇(HDL － C)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL － C)、三酰甘油(Tg)、血清高敏 C 反应蛋白(hs － CRP)水平差异；比较5个月内两组并发症。分析两组临床治疗效果。结果治疗后两组 TC， LDL － C，Tg，hs － CRP 水平均显著降低( P <0.05)，但试验组降低更明显( P <0.05)；5个月内，试验组与对照组 HDL － C 水平、并发症及发生率无明显差异，且无严重并发症。结论老年冠心病患者采用较大剂量阿托伐他汀记录，并发症无明显加重，且还可有效改善炎症因子水平，调节血脂，降低心血管事件的发生。
목적：관찰불동제량아탁벌타정치료노년관상동맥죽양경화성심장병적료효급병발증。방법수궤장128례노년관심병환자분위시험조화대조조，매조64례。재상규치료기출상，대조조구복아탁벌타정15 mg /차；치료조구복아탁벌타정30 mg /차，량조복용아탁벌타정균매천1차，료정위5개월。비교량조치료전후고밀도지단백담고순(HDL － C)、총담고순(TC)、저밀도지단백담고순(LDL － C)、삼선감유(Tg)、혈청고민 C 반응단백(hs － CRP)수평차이；비교5개월내량조병발증。분석량조림상치료효과。결과치료후량조 TC， LDL － C，Tg，hs － CRP 수평균현저강저( P <0.05)，단시험조강저경명현( P <0.05)；5개월내，시험조여대조조 HDL － C 수평、병발증급발생솔무명현차이，차무엄중병발증。결론노년관심병환자채용교대제량아탁벌타정기록，병발증무명현가중，차환가유효개선염증인자수평，조절혈지，강저심혈관사건적발생。
Objective To observe the effect and complications of different doses of atorvastatin in treating senile coronary atherosclerosis heart disease. Methods 128 cases of senile coronary heart disease (CHD) were randomly divided into the eXperimental group and the control group, 64 cases in each group. On the basis of the conventional treatment the control group took oral atorvastatin 15 mg each time, while the eXperimental group took atorvastatin 30 mg each time. Both groups took atorvastatin once a day, with the treatment course of 5 months. The differences of HDL - C, TC, LDL - C, Tg, HS - CRP levels before and after treatment were compared between the two groups; the complications within 5 months were also compared between the two groups. The clinical curative effects were analyzed in the two groups. Results The TC, LDL - C, Tg and hs - CRP levels after treatment were significantly decreased in the two groups( P < 0. 05), but the decrease in the eXperimental group was more significant, the difference between the two groups had statistical significance ( P < 0. 05 ); the HDL - C level, complications and their occurrence rates within 5 months had no statistically significant difference be-tween the two groups. No severe complications occurred in the two groups. Conclusion Adopting larger dose of atorvastatin for treating senile CHD has no obvious aggravation of complications, can effectively improve the inflammatory factors, decrease blood fat and relieve the cardiovascular events occurrence.