中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2014年
23期
21-22
,共2页
应激性溃疡%上消化道出血%奥美拉唑%泮托拉唑%兰索拉唑
應激性潰瘍%上消化道齣血%奧美拉唑%泮託拉唑%蘭索拉唑
응격성궤양%상소화도출혈%오미랍서%반탁랍서%란색랍서
stress ulcer%upper digestive tract hemorrhage%omeprazole%pantoprazole%lansoprazole
目的：观察并比较奥美拉唑、泮托拉唑与兰索拉唑用于预防应激性溃疡的疗效。方法选取2012年1月至2013年12月住院治疗的120例具有消化性溃疡高危因素的患者，并将患者随机分入 A，B，C 3组，分别使用奥美拉唑、泮托拉唑和兰索拉唑预防应激性溃疡。观察各组患者治疗后胃液 pH、上消化道出血发生率及不良反应，以评价3种药物的疗效。结果3组患者用药7 d 后胃液 pH 均显著上升，较治疗前差异有统计学意义（ F =41.29，P <0.001），其中 C 组患者在治疗3 d 后胃液 pH 明显高于另外两组（ F =7.14，P <0.05）；3组患者中应激性溃疡发生率 C 组最低（7.50%），B 组最高（17.50%），但差异无统计学意义（ Z =1.83，P >0.05）；各组腹泻、肌痛、视觉异常和皮炎等不良反应发生率差异无统计学意义（ P >0.05）。结论奥美拉唑、泮托拉唑与雷贝拉唑均可有效预防应激性溃疡，且疗效确切，安全可靠。
目的：觀察併比較奧美拉唑、泮託拉唑與蘭索拉唑用于預防應激性潰瘍的療效。方法選取2012年1月至2013年12月住院治療的120例具有消化性潰瘍高危因素的患者，併將患者隨機分入 A，B，C 3組，分彆使用奧美拉唑、泮託拉唑和蘭索拉唑預防應激性潰瘍。觀察各組患者治療後胃液 pH、上消化道齣血髮生率及不良反應，以評價3種藥物的療效。結果3組患者用藥7 d 後胃液 pH 均顯著上升，較治療前差異有統計學意義（ F =41.29，P <0.001），其中 C 組患者在治療3 d 後胃液 pH 明顯高于另外兩組（ F =7.14，P <0.05）；3組患者中應激性潰瘍髮生率 C 組最低（7.50%），B 組最高（17.50%），但差異無統計學意義（ Z =1.83，P >0.05）；各組腹瀉、肌痛、視覺異常和皮炎等不良反應髮生率差異無統計學意義（ P >0.05）。結論奧美拉唑、泮託拉唑與雷貝拉唑均可有效預防應激性潰瘍，且療效確切，安全可靠。
목적：관찰병비교오미랍서、반탁랍서여란색랍서용우예방응격성궤양적료효。방법선취2012년1월지2013년12월주원치료적120례구유소화성궤양고위인소적환자，병장환자수궤분입 A，B，C 3조，분별사용오미랍서、반탁랍서화란색랍서예방응격성궤양。관찰각조환자치료후위액 pH、상소화도출혈발생솔급불량반응，이평개3충약물적료효。결과3조환자용약7 d 후위액 pH 균현저상승，교치료전차이유통계학의의（ F =41.29，P <0.001），기중 C 조환자재치료3 d 후위액 pH 명현고우령외량조（ F =7.14，P <0.05）；3조환자중응격성궤양발생솔 C 조최저（7.50%），B 조최고（17.50%），단차이무통계학의의（ Z =1.83，P >0.05）；각조복사、기통、시각이상화피염등불량반응발생솔차이무통계학의의（ P >0.05）。결론오미랍서、반탁랍서여뢰패랍서균가유효예방응격성궤양，차료효학절，안전가고。
Objective To investigate the clinical effect of omeprazole, pantoprazole and lansoprazole in preventing stress ulcer(SU) . Methods 120 cases of SU high risk factors in our hospital from Jan. 2012 to Dec. 2013 were selected as the research subjects and randomized assigned into the group A, B and C. The group A, B and C were respectively given omeprazole, pantoprazole and pansopra-zole for preventing SU. The pH value of gastric juice, occurrence rate of upper digestive tract hemorrhage and adverse reactions in each group were observed and the clinical effect of the 3 kinds of drug was evaluated. Results The pH value of gastric juice after 7 d medication showed a significant rise in all groups, the difference between before and after treatment had statistical significance( F =41. 29, P < 0. 001 ) , in which the pH value of gastric juice after 3 d medication in the group C was significant higher than that in the other two groups with statistical difference( F = 7. 14, P < 0. 05 ) ; among 3 groups, the group C had the lowest occurrence rate of SU (7. 50% ) and the group B had the highest occurrence rate of SU(17. 50% ), but the difference had no statistical significance( Z =1. 83, P > 0. 05); the occurrence rates of adverse reactions such as diarrhea, myalgia, paropsia and dermatitis showed no statistical differ-ence among 3 groups( P < 0. 05) . Conclusion Omeprazole, pantoprazole and lansoprazole all can effectively prevent SU with definite effect, safety and reliability.
