中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2014年
23期
8-9
,共2页
甲强龙%咪达唑仑%腰骶部%带状疱疹后神经痛%临床疗效
甲彊龍%咪達唑崙%腰骶部%帶狀皰疹後神經痛%臨床療效
갑강룡%미체서륜%요저부%대상포진후신경통%림상료효
methylprednisolone%midazolam%lumbosacral PHN%clinical effect
目的：观察甲强龙联合咪达唑仑治疗腰骶部带状疱疹神经痛（PHN）的临床疗效。方法选择2012年1月至2013年12月接受治疗的腰骶部 PHN 患者114例，随机分为甲强龙组、咪达唑仑组与联合组，每组38例。甲强龙组硬膜外给予甲强龙、0.9%氯化钠注射液治疗；咪达唑仑组硬膜外给予0.9%氯化钠注射液联合鞘内给予咪达唑仑治疗；联合组硬膜外给予甲强龙联合鞘内给予咪达唑仑治疗。结果3组患者治疗后疼痛视觉模拟评分（VAS）以及睡眠质量评分均明显改善，联合组患者治疗后28，56，84 d 的 VAS 以及睡眠质量得分均显著优于甲强龙组、咪达唑仑组（ P 均<0.05）。3组患者不良反应发生率比较无统计学差异（ P >0.05）。结论甲强龙联合咪达唑仑治疗腰骶部 PHN 的长期镇痛效果良好，不良反应发生率低，安全有效，值得临床应用。
目的：觀察甲彊龍聯閤咪達唑崙治療腰骶部帶狀皰疹神經痛（PHN）的臨床療效。方法選擇2012年1月至2013年12月接受治療的腰骶部 PHN 患者114例，隨機分為甲彊龍組、咪達唑崙組與聯閤組，每組38例。甲彊龍組硬膜外給予甲彊龍、0.9%氯化鈉註射液治療；咪達唑崙組硬膜外給予0.9%氯化鈉註射液聯閤鞘內給予咪達唑崙治療；聯閤組硬膜外給予甲彊龍聯閤鞘內給予咪達唑崙治療。結果3組患者治療後疼痛視覺模擬評分（VAS）以及睡眠質量評分均明顯改善，聯閤組患者治療後28，56，84 d 的 VAS 以及睡眠質量得分均顯著優于甲彊龍組、咪達唑崙組（ P 均<0.05）。3組患者不良反應髮生率比較無統計學差異（ P >0.05）。結論甲彊龍聯閤咪達唑崙治療腰骶部 PHN 的長期鎮痛效果良好，不良反應髮生率低，安全有效，值得臨床應用。
목적：관찰갑강룡연합미체서륜치료요저부대상포진신경통（PHN）적림상료효。방법선택2012년1월지2013년12월접수치료적요저부 PHN 환자114례，수궤분위갑강룡조、미체서륜조여연합조，매조38례。갑강룡조경막외급여갑강룡、0.9%록화납주사액치료；미체서륜조경막외급여0.9%록화납주사액연합초내급여미체서륜치료；연합조경막외급여갑강룡연합초내급여미체서륜치료。결과3조환자치료후동통시각모의평분（VAS）이급수면질량평분균명현개선，연합조환자치료후28，56，84 d 적 VAS 이급수면질량득분균현저우우갑강룡조、미체서륜조（ P 균<0.05）。3조환자불량반응발생솔비교무통계학차이（ P >0.05）。결론갑강룡연합미체서륜치료요저부 PHN 적장기진통효과량호，불량반응발생솔저，안전유효，치득림상응용。
Objective To observe the clinical efficacy of methylprednisolone combined with midazolam in the treatment of lumbosacral postherpetic neuralgia (PHN) . Methods 114 patients with lumbosacral PHN treated in our hospital from January 2012 to December 2013 were selected and randomly divided into the methylprednisolone group, midazolam group and combination group, 38 cases in each group. The methylprednisolone group was given methylprednisolone and 0. 9% NaCl solution by epidural injection; the midazolam group was given 0. 9% NaCl solution by epidural injection combined with midazolam by intrathecal injection; the combination group was given methylprednisolone by epidural injection combined with midazolam by intrathecal injection. Results The VAS and sleep quality scores af-ter treatment in the three groups were significantly improved, the VAS and sleep quality scores on 28, 56, 84 d after treatment in the combination group were significantly superior to those in the methylprednisolone group and the midazolam group with statistically signifi-cant difference( P < 0. 05) . There were no statistically significant differences in the occurrence situation of adverse reactions among the three groups( P > 0. 05). Conclusion methylprednisolone combined with midazolam in treating lumbosacral PHN has long term analgesic effect and low occurrence rate of adverse reactions with safety and effectiveness and is worthy of clinical application.
