中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2014年
23期
4-5
,共2页
花天胶囊%前列腺增生%超氧化物歧化酶%丙二醛
花天膠囊%前列腺增生%超氧化物歧化酶%丙二醛
화천효낭%전렬선증생%초양화물기화매%병이철
Huatian Capsule%BPH%SOD%mDA
目的：观察花天胶囊对前列腺增生大鼠超氧化物歧化酶(SOD)和丙二醛(mDA)的药理作用。方法应用甲睾酮8 mg / kg 灌胃给药，构建前列腺增生模型，各组大鼠（对照组，模型组，前列康组，花天胶囊高、中、低剂量组）连续28 d 给予相应药物或0.9%氯化钠注射液。检测 SOD 活力和 mDA 含量。结果给药后花天胶囊高剂量组大鼠 SOD 活力为（110.58±31.87）U / mgprot，中剂量组大鼠 SOD 活力为（115.70±45.76）U / mgprot，均比模型组明显增加（ P <0.05）；且高剂量组的 mDA 含量为（112.22±32.75）nmoL / mg，明显减少（ P <0.01）。结论花天胶囊可明显增加 SOD 活力、降低 mDA 含量，可能是其抗前列腺增生的作用机制之一，还需进一步研究。
目的：觀察花天膠囊對前列腺增生大鼠超氧化物歧化酶(SOD)和丙二醛(mDA)的藥理作用。方法應用甲睪酮8 mg / kg 灌胃給藥，構建前列腺增生模型，各組大鼠（對照組，模型組，前列康組，花天膠囊高、中、低劑量組）連續28 d 給予相應藥物或0.9%氯化鈉註射液。檢測 SOD 活力和 mDA 含量。結果給藥後花天膠囊高劑量組大鼠 SOD 活力為（110.58±31.87）U / mgprot，中劑量組大鼠 SOD 活力為（115.70±45.76）U / mgprot，均比模型組明顯增加（ P <0.05）；且高劑量組的 mDA 含量為（112.22±32.75）nmoL / mg，明顯減少（ P <0.01）。結論花天膠囊可明顯增加 SOD 活力、降低 mDA 含量，可能是其抗前列腺增生的作用機製之一，還需進一步研究。
목적：관찰화천효낭대전렬선증생대서초양화물기화매(SOD)화병이철(mDA)적약리작용。방법응용갑고동8 mg / kg 관위급약，구건전렬선증생모형，각조대서（대조조，모형조，전렬강조，화천효낭고、중、저제량조）련속28 d 급여상응약물혹0.9%록화납주사액。검측 SOD 활력화 mDA 함량。결과급약후화천효낭고제량조대서 SOD 활력위（110.58±31.87）U / mgprot，중제량조대서 SOD 활력위（115.70±45.76）U / mgprot，균비모형조명현증가（ P <0.05）；차고제량조적 mDA 함량위（112.22±32.75）nmoL / mg，명현감소（ P <0.01）。결론화천효낭가명현증가 SOD 활력、강저 mDA 함량，가능시기항전렬선증생적작용궤제지일，환수진일보연구。
Objective To observe the pharmacological effects of Huatian Capsule on SOD and mDA in rat with prostatic hyperplasia. Methods methyltestosterone 8 mg / kg was given by gastric gavage for 28 d to construct the prostate hyperplasia rat model. meanwhile each group (control group, model group, Qianliekang group, Huatian Capsule high, medium and low doses groups) received the gastric gavage of the corresponding doses or normal saline for consecutive 28 d. The indeXes of the vitality of superoXide dismutase (SOD) and the content of malondialdehyde (mDA) were observed. Results The high and medium doses of Huatian Capsule significantly increased the SOD vitality in rat with prostatic hyperplasia [ (110. 58 ± 31. 87) U / mgprot, (115. 70 ± 45. 76) U / mgprot, P < 0. 05], while the mDA content was significantly decreased when giving the high dose of Huatian Capsule [ (112. 22 ± 32. 75) nmoL / mg, P < 0. 01] . Conclusion Huatian Capsule significantly increases the SOD vitality and obviously decreases the mDA content, which may be caused by the anti -prostate - hyperplasia pharmacological effect of Huatian Capsule, but the further research is needed.
