南通大学学报（医学版）
南通大學學報（醫學版）
남통대학학보（의학판）
JOURNAL OF NANTONG UNIVERSITY(MEDICAL SCIENCES)
2014年
6期
500-502
,共3页
乳腺癌%Pirh2%Naked2
乳腺癌%Pirh2%Naked2
유선암%Pirh2%Naked2
breast cancer%Pirh2%Naked2
目的：分析乳腺癌组织中Pirh2和Naked2的表达情况及其临床意义。方法：随机选取在2011年1月—2013年12月期间收治的96例乳腺癌标本作为观察组，同时选取癌旁组织作为对照组，应用免疫组织化学方法对Pirh2和Naked2表达情况进行检测，分析Pirh2和Naked2表达与乳腺癌病理分级的关系及Pirh2和Naked2两者的相关性。结果：Pirh2在乳腺癌组织中高表达，癌旁组织中低表达，Naked2在乳腺癌组织中低表达，癌旁组织中高表达(P＜0.05)；年龄、肿瘤大小与癌中Pirh2和Naked2的表达无关(P>0.05)；肿瘤病理分级和淋巴结转移与Pirh2和Naked2的表达相关(P＜0.05)；Pirh2和Naked2的表达呈负相关。结论：Pirh2和Naked2对乳腺癌的生物学行为的判断及预后有一定的提示作用。
目的：分析乳腺癌組織中Pirh2和Naked2的錶達情況及其臨床意義。方法：隨機選取在2011年1月—2013年12月期間收治的96例乳腺癌標本作為觀察組，同時選取癌徬組織作為對照組，應用免疫組織化學方法對Pirh2和Naked2錶達情況進行檢測，分析Pirh2和Naked2錶達與乳腺癌病理分級的關繫及Pirh2和Naked2兩者的相關性。結果：Pirh2在乳腺癌組織中高錶達，癌徬組織中低錶達，Naked2在乳腺癌組織中低錶達，癌徬組織中高錶達(P＜0.05)；年齡、腫瘤大小與癌中Pirh2和Naked2的錶達無關(P>0.05)；腫瘤病理分級和淋巴結轉移與Pirh2和Naked2的錶達相關(P＜0.05)；Pirh2和Naked2的錶達呈負相關。結論：Pirh2和Naked2對乳腺癌的生物學行為的判斷及預後有一定的提示作用。
목적：분석유선암조직중Pirh2화Naked2적표체정황급기림상의의。방법：수궤선취재2011년1월—2013년12월기간수치적96례유선암표본작위관찰조，동시선취암방조직작위대조조，응용면역조직화학방법대Pirh2화Naked2표체정황진행검측，분석Pirh2화Naked2표체여유선암병리분급적관계급Pirh2화Naked2량자적상관성。결과：Pirh2재유선암조직중고표체，암방조직중저표체，Naked2재유선암조직중저표체，암방조직중고표체(P＜0.05)；년령、종류대소여암중Pirh2화Naked2적표체무관(P>0.05)；종류병리분급화림파결전이여Pirh2화Naked2적표체상관(P＜0.05)；Pirh2화Naked2적표체정부상관。결론：Pirh2화Naked2대유선암적생물학행위적판단급예후유일정적제시작용。
Objective:To analyze the expression and clinical significance of Pirh2 and Naked2 in breast cancer. Methods:98 breast cancer specimens from Jan.2011 to Dec.2013 were randomly selected as the observation group , while the adjacent tis-sues were selected as a control group. The immunohistochemistry method was used to detect the expression of Pirh2 and Naked2 in 96 breast cancer cases, analyze the pathology character, and then detect the relationship between them. Results:Pirh2 was highly expressed in breast cancer, lowly expressed in adjacent tissues. However Naked2 was lowly expressed in breast cancer tissues, highly expressed in adjacent tissues, the difference was significant(P<0.05). Age and tumor size were no significant difference between Pirh2 and Naked2 expression ( P>0 . 05 ) . Pirh2 and Naked2 were correlated with tumor grade and lymph node metastasis(P<0.05). The expression of Pirh2 and Naked2 in breast cancer tissue was negative(P<0.05). Conclusion:Pirh2 and Naked2 has an important role in the breast cancer and has suggestive action in biological behavior and prognosis of breast cancer.
