CAJ | 학술논문

目的：探讨腺苷激酶(Adenosine kinase，ADK)在乳腺癌组织中的表达情况，并分析其与乳腺癌临床病理特征之间的关系。方法：采用免疫印迹方法检测8对乳腺癌组织和对应癌旁组织中ADK的蛋白表达水平；免疫组织化学方法分析79例乳腺癌组织中ADK的表达；χ2检验分析ADK表达与临床病理因素之间的关系。结果：乳腺癌组织中ADK的蛋白表达明显高于对应癌旁组织。免疫组织化学结果显示ADK的表达在不同病理分级乳腺癌患者中差异有统计学意义(P＜0.05)，与其他病理因素无明显相关性(P>0.05)。结论：ADK在乳腺癌组织中表达上调，提示ADK可能成为乳腺癌潜在的标志物及治疗靶点。
목적：탐토선감격매(Adenosine kinase，ADK)재유선암조직중적표체정황，병분석기여유선암림상병리특정지간적관계。방법：채용면역인적방법검측8대유선암조직화대응암방조직중ADK적단백표체수평；면역조직화학방법분석79례유선암조직중ADK적표체；χ2검험분석ADK표체여림상병리인소지간적관계。결과：유선암조직중ADK적단백표체명현고우대응암방조직。면역조직화학결과현시ADK적표체재불동병리분급유선암환자중차이유통계학의의(P＜0.05)，여기타병리인소무명현상관성(P>0.05)。결론：ADK재유선암조직중표체상조，제시ADK가능성위유선암잠재적표지물급치료파점。
Objective: To analyze the expression of Adenosine kinase(ADK) in breast cancer and the relationship between the expression of ADK and its clinicopathologic variables. Methods: The expression of ADK in 8 pairs of tumor tissues and adjacent nontumorous tissues was detected by Western Blot. Immunohistochemistry technique was used to analyze the expres-sion of ADK in 79 breast cancer samples. The correlation between the expression of ADK and clinical pathological factors was analyzed by chi-square analysis. Results:The expression of ADK was higher in cancer tissues than that in adjacent nontumor-ous tissues and the expression of ADK had a correlation with the histological grade(P<0.05). There was no statistical signifi-cance between the expression of ADK and other pathological factors(P>0.05). Conclusion: ADK was over-expressed in breast cancer and ADK might be a potential marker for breast cancer diagnosis and a potential target for breast cancer therapy.