CAJ | 학술논문

目的：探讨不典型增生在结节性甲状腺肿及癌周组织中的意义.方法选择208例结节性甲状腺肿及52例伴有癌周组织的甲状腺癌标本进行HE染色，光镜观察，并分析病变结构.结果结节性甲状腺肿伴有不典型增生病例为6.3%，其中轻-中度与重度不典型增生病例分别为5.3%和0.96%；癌周组织中伴有不典型增生病例为13.5%，其中轻-中度与重度不典型增生病例分别为7.7%和5.8%.结论不典型增生是甲状腺癌的癌前病变，对结节性甲状腺肿伴有不典型增生病例应密切随访，以防癌变.
목적：탐토불전형증생재결절성갑상선종급암주조직중적의의.방법선택208례결절성갑상선종급52례반유암주조직적갑상선암표본진행HE염색，광경관찰，병분석병변결구.결과결절성갑상선종반유불전형증생병례위6.3%，기중경-중도여중도불전형증생병례분별위5.3%화0.96%；암주조직중반유불전형증생병례위13.5%，기중경-중도여중도불전형증생병례분별위7.7%화5.8%.결론불전형증생시갑상선암적암전병변，대결절성갑상선종반유불전형증생병례응밀절수방，이방암변.
Objective To explore the significance of atypical hyperplasia in nodular goiter and surrounding cancer tissue. Method Specimens of 208 cases with nodular goiter and surrounding cancer tissue specimens of 52 cases with thyroid carcinoma were selected. The specimens were dyed with HE staining and examined with light microscope. Their pathological structures were analyzed. Results Cases of nodular goiter with atypical hyperplasia were 6. 3%,of which slight-middle cases and severe atypical hyperplasia were respectively 5. 3% and 0. 96%;Cases of surrounding cancer tissue with atypical hyperplasia were 13. 5%,of which slight-middle cases and severe atypical hyperplasia were respectively 7 . 7% and 5 . 8%. Conclusion Atypical hyperplasia is a precancerous lesion of thyroid carcinoma. Cases of nodular goiter with atypical hyperplasia should be closely followed up in order to avoid the cancer.