CAJ | 학술논문

目的：分析神经胶质瘤患者术后放疗同步替莫唑胺( Temozolomide,TMZ)化疗的临床疗效及其安全性.方法将收治的86例神经胶质瘤术后患者随机分为两组. A组(43例)采用三维适形放疗同步TMZ化疗,B组(43例)采用单纯三维适形放疗,所有治疗均在术后1个月内开始.比较两组患者的临床疗效、术后1,2,3 a的生存率、Karnofsky评分及毒副作用.结果 A组的客观有效率( Objective response rate,ORR)和疾病控制率( disease control rate,DCR)分别为76.7%和90.7%,显著高于B组(55.8%和74.4%)(P<0.05)；治疗后,两组Karnofsky评分均较治疗前有所提高,且A组显著高于B组(P<0.05)；术后中位生存期及术后1,2,3 a的生存率A组均显著高于B组(P<0.05)；两组治疗期间的毒副作用比较无统计学意义(P>0.05).结论放疗同步TMZ化疗是神经胶质瘤术后一种安全、有效的辅助治疗方法,可提高近远期疗效和术后的生存率,且并不增加药物毒性作用.
목적：분석신경효질류환자술후방료동보체막서알( Temozolomide,TMZ)화료적림상료효급기안전성.방법장수치적86례신경효질류술후환자수궤분위량조. A조(43례)채용삼유괄형방료동보TMZ화료,B조(43례)채용단순삼유괄형방료,소유치료균재술후1개월내개시.비교량조환자적림상료효、술후1,2,3 a적생존솔、Karnofsky평분급독부작용.결과 A조적객관유효솔( Objective response rate,ORR)화질병공제솔( disease control rate,DCR)분별위76.7%화90.7%,현저고우B조(55.8%화74.4%)(P<0.05)；치료후,량조Karnofsky평분균교치료전유소제고,차A조현저고우B조(P<0.05)；술후중위생존기급술후1,2,3 a적생존솔A조균현저고우B조(P<0.05)；량조치료기간적독부작용비교무통계학의의(P>0.05).결론방료동보TMZ화료시신경효질류술후일충안전、유효적보조치료방법,가제고근원기료효화술후적생존솔,차병불증가약물독성작용.
Objective To explore the clinical efficacy and safety of radiotherapy combined with temozolomide ( TMZ ) chemotherapy for postoperative glioma. Method Eighty-six patients with postoperative glioma were randomly divided into two groups, namely, group A ( n=43 ) and group B ( n=43 ) . Patients in group A were treated with three-dimensional conformal radiotherapy combined with TMZ,and those in group B were treated with three-dimensional conformal radiotherapy only. After the treatment for 1 month,the effective rate,1-year,2-year and 3-year survival rates,Karnofsky scores,and toxic and side effects of patients in two groups were compared. Results ORR( Objective response rate ) and DCR ( disease control rate ) in group A ( 76. 7% and 90. 7%respectively)were significantly higher than those in group B(55. 8% and 74. 4% respectively) (P<0. 05). Karnofsky scores increased in both groups after the treatment,and the increase degree was significantly higher in group A than that in group B(P<0. 05). The median survival time,1-year,2-year and 3-year survival rates after the operation in group A were significantly higher than those in group B ( P<0 . 05 ) . There was no significant difference in the toxic and side effects between the two groups ( P>0 . 05 ) . Conclusions The radiotherapy combined with TMZ chemotherapy is an effective and well-tolerable auxiliary therapy for postoperative glioma. It can improve the short-term and long-term effect,and the survival rate of the patients without increasing toxic and side effects of drug.