中国感染控制杂志
中國感染控製雜誌
중국감염공제잡지
CHINESE JOURNAL OF INFECTION CONTROL
2014年
11期
669-673
,共5页
糖尿病%糖尿病足%溃疡%感染%病原菌%耐药性%抗药性,微生物
糖尿病%糖尿病足%潰瘍%感染%病原菌%耐藥性%抗藥性,微生物
당뇨병%당뇨병족%궤양%감염%병원균%내약성%항약성,미생물
diabetes%diabetic foot%ulcer%infection%pathogen%drug resistance%drug resistance,microbial
目的:了解糖尿病足溃疡部位感染的病原菌分布及其耐药性。方法2012年6月—2013年6月,使用无菌拭子采集青岛市中心医疗集团所属各医院以及周边社区医院内分泌科、烧伤整形科等科室就诊糖尿病足患者溃疡部位分泌物,浸于无菌肉汤中送检,做细菌培养和药敏试验。结果共采集137例患者的标本,培养分离到病原菌216株,其中革兰阴性杆菌127株(58.80%),革兰阳性球菌86株(39.81%),真菌3株(1.39%);其中单一病原菌感染76例(55.47%),混合病原菌感染61例(44.53%);检出数量前5位分别为铜绿假单胞菌(37株)、金黄色葡萄球菌(35株)、大肠埃希菌(26株)、表皮葡萄球菌(24株)和鲍曼不动杆菌(22株)。肠杆菌科细菌对阿米卡星、阿莫西林/克拉维酸、头孢西丁、亚胺培南、哌拉西林/他唑巴坦、替卡西林/克拉维酸的耐药率(0~16.67%)较低;铜绿假单胞菌对亚胺培南、妥布霉素、阿米卡星、头孢吡肟、庆大霉素、喹诺酮类药物耐药率(2.70%~18.92%)较低;鲍曼不动杆菌耐药情况最为严重,除亚胺培南和左氧氟沙星外,耐药率均在30%以上。结论该地区糖尿病足溃疡部位病原菌感染以革兰阴性杆菌为主,其次为革兰阳性球菌,各菌属的耐药性有较大差异,临床医生应根据药敏结果合理选择抗菌药物。
目的:瞭解糖尿病足潰瘍部位感染的病原菌分佈及其耐藥性。方法2012年6月—2013年6月,使用無菌拭子採集青島市中心醫療集糰所屬各醫院以及週邊社區醫院內分泌科、燒傷整形科等科室就診糖尿病足患者潰瘍部位分泌物,浸于無菌肉湯中送檢,做細菌培養和藥敏試驗。結果共採集137例患者的標本,培養分離到病原菌216株,其中革蘭陰性桿菌127株(58.80%),革蘭暘性毬菌86株(39.81%),真菌3株(1.39%);其中單一病原菌感染76例(55.47%),混閤病原菌感染61例(44.53%);檢齣數量前5位分彆為銅綠假單胞菌(37株)、金黃色葡萄毬菌(35株)、大腸埃希菌(26株)、錶皮葡萄毬菌(24株)和鮑曼不動桿菌(22株)。腸桿菌科細菌對阿米卡星、阿莫西林/剋拉維痠、頭孢西丁、亞胺培南、哌拉西林/他唑巴坦、替卡西林/剋拉維痠的耐藥率(0~16.67%)較低;銅綠假單胞菌對亞胺培南、妥佈黴素、阿米卡星、頭孢吡肟、慶大黴素、喹諾酮類藥物耐藥率(2.70%~18.92%)較低;鮑曼不動桿菌耐藥情況最為嚴重,除亞胺培南和左氧氟沙星外,耐藥率均在30%以上。結論該地區糖尿病足潰瘍部位病原菌感染以革蘭陰性桿菌為主,其次為革蘭暘性毬菌,各菌屬的耐藥性有較大差異,臨床醫生應根據藥敏結果閤理選擇抗菌藥物。
목적:료해당뇨병족궤양부위감염적병원균분포급기내약성。방법2012년6월—2013년6월,사용무균식자채집청도시중심의료집단소속각의원이급주변사구의원내분비과、소상정형과등과실취진당뇨병족환자궤양부위분비물,침우무균육탕중송검,주세균배양화약민시험。결과공채집137례환자적표본,배양분리도병원균216주,기중혁란음성간균127주(58.80%),혁란양성구균86주(39.81%),진균3주(1.39%);기중단일병원균감염76례(55.47%),혼합병원균감염61례(44.53%);검출수량전5위분별위동록가단포균(37주)、금황색포도구균(35주)、대장애희균(26주)、표피포도구균(24주)화포만불동간균(22주)。장간균과세균대아미잡성、아막서림/극랍유산、두포서정、아알배남、고랍서림/타서파탄、체잡서림/극랍유산적내약솔(0~16.67%)교저;동록가단포균대아알배남、타포매소、아미잡성、두포필우、경대매소、규낙동류약물내약솔(2.70%~18.92%)교저;포만불동간균내약정황최위엄중,제아알배남화좌양불사성외,내약솔균재30%이상。결론해지구당뇨병족궤양부위병원균감염이혁란음성간균위주,기차위혁란양성구균,각균속적내약성유교대차이,림상의생응근거약민결과합리선택항균약물。
Objective To investigate the distribution and antimicrobial resistance of pathogens causing diabetic foot ulcer(DFU). Methods Secretion specimens of DFU in patients at several hospitals in Qingdao were collected and performed bacterial culture and antimicrobial susceptibility testing. Results A total of 216 pathogens were ob-tained from 137 patients with DFU. Isolation rate of gram-negative bacilli,gram-positive cocci and fungi was 58.80% (n= 127),39.81% (n= 86)and 1.39% (n= 3)respectively. 76 (55.47% )patients were infected with sin-gle pathogen,61 (44.53% )were infected with mixed pathogens;the top five detected pathogens were Pseudomonas aeruginosa(n= 37),Staphylococcusaureus (n= 35),Escherichiacoli (n= 26),Staphylococcusepidermidis(n=24),and Acinetobacterbaumannii(n= 22). The resistance of Enterobacteriaceae to amikacin,amoxicillin/clavu-lanic acid,cefoxitin,imipenem,piperacillin/tazobactam,ticarcillin/clavulanic acid were 0-16.67% ;the resist-ance of Pseudomonas aeruginosa to imipenem,tobramycin,amikacin,cefepime,gentamicin,and quinolones were 2 .70% -1 8 .92% ;the resistance of Acinetobacterbaumannii to imipenem and levofloxacin were low,but to the other antimicrobial agents were all above 30% . Conclusion The major pathogens from DFU were gram-negative bacilli, the next were gram-positive cocci,antimicrobial resistance patterns of each species are quite different,clinicians should choose antimicrobial agents according to antimicrobial susceptibility testing results.