CAJ | 학술논문

目的：了解铜绿假单胞菌耐药率及其与住院患者抗菌药物使用强度（AUD）间的关系，为医院感染控制工作提供参考。方法对2011年7月—2013年12月某医院住院患者分离的铜绿假单胞菌耐药率及同期住院患者AUD进行监测，并对两者进行相关性分析。结果该院住院患者总 AUD 从2011年第三、四季度的73．61下降至2013年第三、四季度的41．33。住院患者AUD与铜绿假单胞菌耐药率相关性分析，相关系数r为－0．32～0．88，其中铜绿假单胞菌对氨曲南耐药率与氨曲南使用强度相关系数为0．88，其相关性具有统计学意义。结论住院患者AUD下降，铜绿假单胞菌的耐药率呈现下降趋势，提示临床应考虑抗菌药物的选择性筛选耐药。
목적：료해동록가단포균내약솔급기여주원환자항균약물사용강도（AUD）간적관계，위의원감염공제공작제공삼고。방법대2011년7월—2013년12월모의원주원환자분리적동록가단포균내약솔급동기주원환자AUD진행감측，병대량자진행상관성분석。결과해원주원환자총 AUD 종2011년제삼、사계도적73．61하강지2013년제삼、사계도적41．33。주원환자AUD여동록가단포균내약솔상관성분석，상관계수r위－0．32～0．88，기중동록가단포균대안곡남내약솔여안곡남사용강도상관계수위0．88，기상관성구유통계학의의。결론주원환자AUD하강，동록가단포균적내약솔정현하강추세，제시림상응고필항균약물적선택성사선내약。
Objective To realize antimicrobial resistance rate of Pseudomonas aeruginosa (P. aeruginosa)and it’s correlation with antimicrobial use density(AUD),and to provide reference for control of healthcare-associated infec-tion.Methods From July 2011 to December 2013,antimicrobial resistance rate of P. aeruginosa isolated from hospi-talized patients and AUD of patients were monitored,and the correlation between them was analyzed.Results AUD of patients decreased from 73.61 in the third and fourth quarters of 2011 to 41.33 in the same quarters of 2013. Corre-lation coefficient of AUD and antimicrobial resistance rate of P. aeruginosa was -0.32~0.88,correlation coeffi-cient of resistance rate of P. aeruginosa to aztreonam and aztreonam use density was 0.88,there was statistical sig-nificance. Conclusion AUD of hospitalized patients revealed a decreasing tendency,suggesting antimicrobial selec-tive resistance should be considered in clinic.