CAJ | 학술논문

目的：探讨新生儿血清Toll样受体(TLR)-4、肿瘤坏死因子(TNF)-α、白介素(IL)-6与早产的关系及意义。方法新生儿120例分为足月新生儿40例，胎膜早破早产儿40例，特发性早产儿40例。均在出生30 min内采集外周静脉血。应用酶联免疫法(ELISA)检测新生儿血清TLR-4、TNF-α和IL-6水平。结果胎膜早破早产儿、特发性早产儿的血清TLR-4、TNF-α、IL-6水平均高于足月儿(P均<0.05)。两组早产儿的TLR-4均分别与该组TNF-α和IL-6水平呈正相关性；而TNF-α和IL-6水平之间也呈正相关性(P均<0.01)。结论 TLR-4、TNF-α、IL-6水平的改变可能与早产相关。
목적：탐토신생인혈청Toll양수체(TLR)-4、종류배사인자(TNF)-α、백개소(IL)-6여조산적관계급의의。방법신생인120례분위족월신생인40례，태막조파조산인40례，특발성조산인40례。균재출생30 min내채집외주정맥혈。응용매련면역법(ELISA)검측신생인혈청TLR-4、TNF-α화IL-6수평。결과태막조파조산인、특발성조산인적혈청TLR-4、TNF-α、IL-6수평균고우족월인(P균<0.05)。량조조산인적TLR-4균분별여해조TNF-α화IL-6수평정정상관성；이TNF-α화IL-6수평지간야정정상관성(P균<0.01)。결론 TLR-4、TNF-α、IL-6수평적개변가능여조산상관。
Objective To explore the roles of serum TLR-4, TNF-αand IL-6 in neonates with preterm birth. Methods A total of 120 neonates from neonatology department in the Xingtai People's Hospital were selected and divided into full-term group (n=40), premature rupture of fetal membranes (n=40) and idiopathic preterm group (n=40) based on the gestational age. The peripheral venous blood was collected within 30 minutes when the infants were born, and the supernatant was reserved after centrifuged. The levels of serum TLR-4, TNF-αand IL-6 were detected by enzyme-linked immunosorbent assay. Results The levels of TLR-4, TNF-αand IL-6 in idiopathic preterm and premature rupture of fetal membranes were signiifcantly higher than that in full-term group and showed positive correlation. Conclusion Cytokines TLR-4, TNF-αand IL-6 maybe closely related to the preterm birth.