CAJ | 학술논문

目的：观察硫酸镁对促肾上腺皮质激素(ACTH)治疗婴儿痉挛症(IS)过程中高血压的预防作用。方法选取2011年5月至2013年10月住院的46例IS患儿，以入住医院分为硫酸镁组23例，给予硫酸镁联合ACTH治疗；对照组23例，单用ACTH治疗，疗程均为2周。观察比较两组高血压的发生率。结果硫酸镁组患儿没有出现高血压，全部完成疗程；对照组出现6例高血压，18例完成疗程。硫酸镁组在高血压的发生及疗程完成方面均优于对照组，差异有统计学意义(P<0.05)。结论硫酸镁能预防ACTH在治疗IS过程中高血压的发生，有利于完成疗程，尽早控制病情。
목적：관찰류산미대촉신상선피질격소(ACTH)치료영인경련증(IS)과정중고혈압적예방작용。방법선취2011년5월지2013년10월주원적46례IS환인，이입주의원분위류산미조23례，급여류산미연합ACTH치료；대조조23례，단용ACTH치료，료정균위2주。관찰비교량조고혈압적발생솔。결과류산미조환인몰유출현고혈압，전부완성료정；대조조출현6례고혈압，18례완성료정。류산미조재고혈압적발생급료정완성방면균우우대조조，차이유통계학의의(P<0.05)。결론류산미능예방ACTH재치료IS과정중고혈압적발생，유리우완성료정，진조공제병정。
Objective To examine the preventive effect of magnesium sulfate on hypertension caused by ACTH in the treatment of infantile spasms (IS). Methods 46 children diagnosed as IS were recruited from two hospitals during May, 2011 to October, 2013.23 patients in group A (treatment group) were treated with magnesium sulfate and ACTH in hospital A;another 23 cases in group B (control group) were treated with ACTH only in hospital B. The therapy course was 2 weeks. Results Hyperten-sion was not observed in the treatment group, while 6 children were observed with hypertension in the control group. There was signiifcant difference between the two groups (P<0.05). Conclusions Magnesium sulfate could prevent the incidence of hyper-tension in the treatment of IS with ACTH, and beneift the completion of treatment course.