江西医药
江西醫藥
강서의약
JIANGXI MEDICAL JOURNAL
2014年
11期
1134-1137
,共4页
吴爱民%陈强%刘建梅%李岚%张帆%吴丹遐
吳愛民%陳彊%劉建梅%李嵐%張帆%吳丹遐
오애민%진강%류건매%리람%장범%오단하
支气管哮喘%25-羟维生素D3%TIgE%sIgE%肺功能
支氣管哮喘%25-羥維生素D3%TIgE%sIgE%肺功能
지기관효천%25-간유생소D3%TIgE%sIgE%폐공능
Asthma%25-(OH)D3%TIgE%SIgE%Pulmonary function
目的：研究支气管哮喘儿童血清25-羟胆骨化醇[25-(OH)D3]、总免疫球蛋白E(TIgE)及特异性IgE（sIgE）的变化及临床意义。方法将60例健康体检儿童为对照组，180例确诊为支气管哮喘的患儿为哮喘组，哮喘组根据年龄分为婴幼儿组（<5岁）60例及儿童组（≥5岁）120例，分别进行过敏原特异性IgE（采用免疫印迹法）、血清总IgE，血清25-(OH)D3的检测及肺功能（5岁以上）及气道阻力测定（5岁以下），比较组间各项指标的差异。结果哮喘组血清25-(OH)D3含量(28.14±9.34) nmol/L明显低于对照组(74.41±10.75)nmol/mL，且TIgE含量(300.01±102.13)IU/mL明显高于正常对照组(138.12±45.12)I-U/mL，哮喘组sIgE阳性检出率明显高于正常对照组，差异均有统计学意义(P<0.01)。哮喘组血清25-(OH)D3与TIgE呈负相关(r=-0.655，P<0.01)，血清25-(OH)D3水平与sIgE阳性之间存在相关性(χ2=19.432，P<0.01)。儿童组sIgE阳性中食入性过敏原占25.86％，吸入性占74.14％；婴幼儿组sIgE阳性中食入性过敏原占70.21％，吸入性占29.79％；两组sIgE阳性吸入性、食入性过敏原构成有统计学差异(P<0.05)。哮喘患者血清25-(OH)D3与FEV1%pred呈正相关（r=0.568，P<0.01）。哮喘患者血清25-(OH)D3与气道阻力呈负相关（r=-0.439，P<0.01）。结论血清25-(OH)D3缺乏及不足与支气管哮喘发病存在联系，推断血清25-(OH)D3水平增高可以抑制IgE的过度表达，纠正血清25-(OH)D3水平缺乏、不足，可能改善哮喘患儿肺功能、减少过敏发生率，故补充维生素D可能成为预防和治疗支气管哮喘的一种新的有效方法。
目的：研究支氣管哮喘兒童血清25-羥膽骨化醇[25-(OH)D3]、總免疫毬蛋白E(TIgE)及特異性IgE（sIgE）的變化及臨床意義。方法將60例健康體檢兒童為對照組，180例確診為支氣管哮喘的患兒為哮喘組，哮喘組根據年齡分為嬰幼兒組（<5歲）60例及兒童組（≥5歲）120例，分彆進行過敏原特異性IgE（採用免疫印跡法）、血清總IgE，血清25-(OH)D3的檢測及肺功能（5歲以上）及氣道阻力測定（5歲以下），比較組間各項指標的差異。結果哮喘組血清25-(OH)D3含量(28.14±9.34) nmol/L明顯低于對照組(74.41±10.75)nmol/mL，且TIgE含量(300.01±102.13)IU/mL明顯高于正常對照組(138.12±45.12)I-U/mL，哮喘組sIgE暘性檢齣率明顯高于正常對照組，差異均有統計學意義(P<0.01)。哮喘組血清25-(OH)D3與TIgE呈負相關(r=-0.655，P<0.01)，血清25-(OH)D3水平與sIgE暘性之間存在相關性(χ2=19.432，P<0.01)。兒童組sIgE暘性中食入性過敏原佔25.86％，吸入性佔74.14％；嬰幼兒組sIgE暘性中食入性過敏原佔70.21％，吸入性佔29.79％；兩組sIgE暘性吸入性、食入性過敏原構成有統計學差異(P<0.05)。哮喘患者血清25-(OH)D3與FEV1%pred呈正相關（r=0.568，P<0.01）。哮喘患者血清25-(OH)D3與氣道阻力呈負相關（r=-0.439，P<0.01）。結論血清25-(OH)D3缺乏及不足與支氣管哮喘髮病存在聯繫，推斷血清25-(OH)D3水平增高可以抑製IgE的過度錶達，糾正血清25-(OH)D3水平缺乏、不足，可能改善哮喘患兒肺功能、減少過敏髮生率，故補充維生素D可能成為預防和治療支氣管哮喘的一種新的有效方法。
목적：연구지기관효천인동혈청25-간담골화순[25-(OH)D3]、총면역구단백E(TIgE)급특이성IgE（sIgE）적변화급림상의의。방법장60례건강체검인동위대조조，180례학진위지기관효천적환인위효천조，효천조근거년령분위영유인조（<5세）60례급인동조（≥5세）120례，분별진행과민원특이성IgE（채용면역인적법）、혈청총IgE，혈청25-(OH)D3적검측급폐공능（5세이상）급기도조력측정（5세이하），비교조간각항지표적차이。결과효천조혈청25-(OH)D3함량(28.14±9.34) nmol/L명현저우대조조(74.41±10.75)nmol/mL，차TIgE함량(300.01±102.13)IU/mL명현고우정상대조조(138.12±45.12)I-U/mL，효천조sIgE양성검출솔명현고우정상대조조，차이균유통계학의의(P<0.01)。효천조혈청25-(OH)D3여TIgE정부상관(r=-0.655，P<0.01)，혈청25-(OH)D3수평여sIgE양성지간존재상관성(χ2=19.432，P<0.01)。인동조sIgE양성중식입성과민원점25.86％，흡입성점74.14％；영유인조sIgE양성중식입성과민원점70.21％，흡입성점29.79％；량조sIgE양성흡입성、식입성과민원구성유통계학차이(P<0.05)。효천환자혈청25-(OH)D3여FEV1%pred정정상관（r=0.568，P<0.01）。효천환자혈청25-(OH)D3여기도조력정부상관（r=-0.439，P<0.01）。결론혈청25-(OH)D3결핍급불족여지기관효천발병존재련계，추단혈청25-(OH)D3수평증고가이억제IgE적과도표체，규정혈청25-(OH)D3수평결핍、불족，가능개선효천환인폐공능、감소과민발생솔，고보충유생소D가능성위예방화치료지기관효천적일충신적유효방법。
Objective To study the changes and clinical significance of serum levels of 25-(OH)D3,total IgE and specific IgE in children with asthma. Methods 60 cases healthy children who did health examination were selected as health control group , 180 cases children diagnosed as asthma were selected as asthma group,asthma group was divided into infant group (<5years) with 60 cases and children group (≥5years) with 120 cases. Respectively,all cases were detected with serum levels of allergen specific IgE(by Western blot),total IgE and 25-(OH)D3,and measured with pulmonary function(≥5years) and airway resistance (<5years), compare the differences in the indexes in each group. Results Serum 25-(OH)D3 levels (28.14±9.34)nmol/L decreased significant-ly in asthma group compared with thoes in control group (74.41±10.75)nmol/mL,serum total IgE levels increased significantly in asthma group (300.01±102.13)IU/mL compared with those in control group (138.12±45.12)IU/ml,the positive rate of specific IgE in asthma group was significantly higher than that in control group (P<0.01). In asthma group,serum 25-(OH)D3 levels were negative-ly correlated with serum total IgE levels (r=-0.655,P<0.01),and there was a correlation between serum 25-(OH)D3 levels and spe-cific IgE-positive (χ2=19.432,P<0.01). Among the sIgE-positive in children group,food allergens accounted for 25.86%,inhaled allergens accounted for 74.14%;among the sIgE-positive in infant group,food allergens accounted for 70.21%,inhaled allergens accounted for 29.79%;the constitution of food allergens and inhaled allergens of sIgE-positive between these two groups had sta-tistical differences (P<0.05). In asthma group,serum 25-(OH)D3 levels were negatively correlated with FEV1%pred (r=0.568,P<0. 01) and airway resistance (r=-0.439,P<0.01). Conclusion Serum 25-(OH)D3 deficiency is associated with the pathogenesis of asthma. The increased serum 25-(OH)D3 level may inhibit IgE expression,improve pulmonary function in children with asthma,re-duce the incidence of allergy. Vitamin D supplements may become a new effective method for the prevention and treatment of asth-ma.
