CAJ | 학술논문

目的：探讨慢性肾脏病（ chronic kidney disease，CKD）患者认知功能与胰岛素抵抗（ IR）的关系。方法将101例CKD3～4期患者分为两组：合并认知功能损害患者组38例，认知功能正常组63例，比较两组间性别、年龄、BMI、TC、TG、CRP、内生肌酐清除率（ CCr）、HOMA－IR、颈动脉内膜中层厚度（ intima －media thickness， IMT）、收缩压（ SBP）和舒张压（ DBP）的差别，并进行Logistic回归分析。结果与认知功能正常组相比，慢性肾脏病合并认知功能损害组BMI、TG、FINS、CRP、IMT及HOMA－IR较高（ P＜0．05）；Logistic回归分析显示IMT、CCr及HOMA－IR对认知功能障碍的发病具有相关性。结论 HOMA－IR、IMT及CCr是认知功能障碍的独立危险因素。
목적：탐토만성신장병（ chronic kidney disease，CKD）환자인지공능여이도소저항（ IR）적관계。방법장101례CKD3～4기환자분위량조：합병인지공능손해환자조38례，인지공능정상조63례，비교량조간성별、년령、BMI、TC、TG、CRP、내생기항청제솔（ CCr）、HOMA－IR、경동맥내막중층후도（ intima －media thickness， IMT）、수축압（ SBP）화서장압（ DBP）적차별，병진행Logistic회귀분석。결과여인지공능정상조상비，만성신장병합병인지공능손해조BMI、TG、FINS、CRP、IMT급HOMA－IR교고（ P＜0．05）；Logistic회귀분석현시IMT、CCr급HOMA－IR대인지공능장애적발병구유상관성。결론 HOMA－IR、IMT급CCr시인지공능장애적독립위험인소。
Objective To explore the relationship between cognitive impairment and insulin resistance in patients with chronic kidney disease( CKD).Methods One hundred and one cases of 3~4 CKD patients were divided into two groups:cognitive impairment group and non-cognitive impairment group.The weight,body mass index( BMI) ,fasting se-rum glucose,insulin,total cholesterol(TC),triglyceride(TG),intima -media thickness(IMT) and CRP were detec-ted.The difference of these indexes and HOMA-IR were compared between cognitive impairment group and non-cogni-tive impairment group.Results Compared with non-cognitive impairment group, the BMI, FPG, TG, CRP, IMT, CCr and HOMA-IR in cognitive impairment group increased markedly (P<0.05),CCr was lower.The Logistic regression a-nalysis showed that CCr,HOMA-IR,and CRP had an impact on the incidence of cognitive impairment.Conclusions HOMA-IR,CRP and CCr were the independent risk factors for developing cognitive impairment in patients with chronic kidney disease.