CAJ | 학술논문

目的：观察CT引导下靶位注射胶原酶治疗腰椎间盘突出症的临床效果。方法选择2011年1月至2013年1月收治的腰椎间盘突出症患者72例，其中男42例，女30例，年龄20~69岁。按照随机数字法分为两组，每组36例。观察组CT引导下靶位注射胶原酶治疗，对照组凭经验非CT引导注射胶原酶治疗。随访6个月，比较治疗前及治疗6个月后疼痛评分情况，并进行疗效评定。结果观察组穿刺一次成功31例（86.11%），明显优于对照组（ P<0.05）；观察组疗效优27例（75.00%），良6例（16.67%），尚可2例（5.56%），差1例（2.78%），优良率达33例（91.67%）；对照组优良26例（72.22%），差异明显（ P<0.05）；观察组治疗后疼痛视觉模拟( VAS )评分为（3.56±1.11）分，明显优于对照组的（6.54±1.16）分（ P<0.05），且明显优于治疗前（7.98±1.35）分（ P<0.05）。结论 CT引导下靶位注射胶原酶治疗腰椎间盘突出症临床效果较佳，缓解疼痛显著，具有重要的临床价值。
목적：관찰CT인도하파위주사효원매치료요추간반돌출증적림상효과。방법선택2011년1월지2013년1월수치적요추간반돌출증환자72례，기중남42례，녀30례，년령20~69세。안조수궤수자법분위량조，매조36례。관찰조CT인도하파위주사효원매치료，대조조빙경험비CT인도주사효원매치료。수방6개월，비교치료전급치료6개월후동통평분정황，병진행료효평정。결과관찰조천자일차성공31례（86.11%），명현우우대조조（ P<0.05）；관찰조료효우27례（75.00%），량6례（16.67%），상가2례（5.56%），차1례（2.78%），우량솔체33례（91.67%）；대조조우량26례（72.22%），차이명현（ P<0.05）；관찰조치료후동통시각모의( VAS )평분위（3.56±1.11）분，명현우우대조조적（6.54±1.16）분（ P<0.05），차명현우우치료전（7.98±1.35）분（ P<0.05）。결론 CT인도하파위주사효원매치료요추간반돌출증림상효과교가，완해동통현저，구유중요적림상개치。
Objective To observe the clinical effect of CT guiding targeted collagenase injection in the treatment of protrusion of lumbar intervertebral disc. Methods 72 cases of protrusion of lumbar intervertebral disc treated in our hospital from January 2011 to January 2013 were selected as the research subjects and consistent with the diagnosis of protrusion of lumbar intervertebral disc, including 42 males and 30 females aged 20-69 years old. They were randomly divided into two groups according to the random number table, 36 cases in each group. The observation group adopted CT guiding targeted collagenase injection, while the control group took the collage-nase injection by experience without CT guiding. The two groups were followed up for 6 months. Then the pain scores were compared between before treatment and after 6-month treatment. And the curative effect was evaluated. Results 31 cases ( 86. 11%) in the ob-servation group were the once puncture success, which was significantly better than that in the control group ( P<0. 05 );in the observa-tion group, the excellent effect was in 27 cases ( 75. 00%) , good effect in 6 cases ( 16. 67%) , fair effect in 2 cases ( 5. 56%) and poor effect in 1 case ( 2. 78% ) , the excellent and good effects were achieved in 33 cases ( 91. 67% );but in the control group, the excellent and good effects were in 26 cases ( 72. 22% ) , the difference showed the statistical significance ( P<0. 05 ); the observation group was significantly superior to the control group in the VAS scores after treatment [ ( 3. 56 ± 1. 11 ) points vs. ( 6. 54 ± 1. 16 ) points, P< 0. 05 ] , moreover significantly superior to before treatment [ ( 3. 56 ± 1. 11 ) points vs. ( 7. 98 ± 1. 35 ) points, P<0. 05 ] . Conclusion CT guiding targeted collagenase injection has good clinical effect in the treatment of protrusion of lumbar intervertebral disc, can relieve pain obvi-ously and has important clinical value.