CAJ | 학술논문

线粒体控制着细胞凋亡的激活系统。肿瘤细胞的多种特征，包括无限的增殖能力、对抑制生长信号的不敏感、受损的细胞凋亡机制等都与线粒体的机能丧失有关。研究发现，肥胖、糖尿病等疾病的发生发展过程中均存在线粒体功能的紊乱，并且多种疾病的发生与线粒体DNA的变异有关。因此，为了防止或修复线粒体功能的损伤，寻找靶向线粒体的递药系统越来越重要。针对线粒体的结构特征，该文综述了国内外不同线粒体靶向策略的研究进展。
선립체공제착세포조망적격활계통。종류세포적다충특정，포괄무한적증식능력、대억제생장신호적불민감、수손적세포조망궤제등도여선립체적궤능상실유관。연구발현，비반、당뇨병등질병적발생발전과정중균존재선립체공능적문란，병차다충질병적발생여선립체DNA적변이유관。인차，위료방지혹수복선립체공능적손상，심조파향선립체적체약계통월래월중요。침대선립체적결구특정，해문종술료국내외불동선립체파향책략적연구진전。
Mitochondria controls the activation system of apoptosis, a variety of characteristics of tumor cells, including unlimited prolifera-tion ability, unsensitive to the signals of growth inhibition and the damaged apoptosis mechanism, are related to the function loss of mi-tochondria. Some researches found that the mitochondrial function disorder exists in the occurrence and development of some diseases, such as obesity and diabetes, and the occurrences of many diseases have a relationship with the DNA mutation of mitochondria. Therefore, in order to prevent or repair the damaged function of mitochondrion, looking for the drug delivery systems targeting mitochon-dria is more and more important. Aiming at the mitochondrial structure characteristics, this paper reviews the research advances in differ-ent mitochondrial targeting strategies at home and abroad.