CAJ | 학술논문

目的：旨在探讨阿尔茨海默病( AD)和非缺血性轻度认知功能障碍( MCI)患者的血脂水平，从而探讨血脂与认知功能的关系。方法收集住院的老年患者282例，根据诊断标准分为AD组、MCI组和认知功能正常组(对照组)，调查血脂水平，并用单因素和多因素分析进行统计。结果单因素分析结果显示血清总胆固醇、低密度脂蛋白在AD组和正常对照组相比有显著性差异，低密度脂蛋白在MCI组和AD组中差异也有显著性。多因素分析结果显示血清总胆固醇和低密度脂蛋白与MoCA量表评分具有相关性。结论本研究提示控制血清总胆固醇和低密度脂蛋白可以减少AD 的发病，延缓病情的进展。
목적：지재탐토아이자해묵병( AD)화비결혈성경도인지공능장애( MCI)환자적혈지수평，종이탐토혈지여인지공능적관계。방법수집주원적노년환자282례，근거진단표준분위AD조、MCI조화인지공능정상조(대조조)，조사혈지수평，병용단인소화다인소분석진행통계。결과단인소분석결과현시혈청총담고순、저밀도지단백재AD조화정상대조조상비유현저성차이，저밀도지단백재MCI조화AD조중차이야유현저성。다인소분석결과현시혈청총담고순화저밀도지단백여MoCA량표평분구유상관성。결론본연구제시공제혈청총담고순화저밀도지단백가이감소AD 적발병，연완병정적진전。
Objective To explore the blood lipid levels of Alzheimer′s Disease ( AD) and non ischemic Mild Cogni-tive Impairment ( MCI) , and to prevent occurrence and development of the diseases by controlling the blood lipids. Method Collected 282 cases of elderly patients in hospital according to diagnostic criteria are divided into AD group, the MCI group and cognitive function in normal group ( control group) , investigation and lipid levels, and single factor and multiple factors analysis in statistics. Result Single factor analysis showed that the serum total cho-lesterol, low density lipoprotein in AD group were significantly different compared with the normal control group, low density lipoprotein also had significant difference between MCI and AD groups. The results of multivariate anal-ysis showed that the serum total cholesterol and low density lipoprotein and MoCA score correlated, but not inde-pendently related to. Conclusion This study indicated that control of serum total cholesterol and low density lipopro-tein can reduce the incidence and delay the progression of AD.