浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2014年
22期
1867-1869
,共3页
Ki67%CA125%腹壁切口%子宫内膜异位症
Ki67%CA125%腹壁切口%子宮內膜異位癥
Ki67%CA125%복벽절구%자궁내막이위증
Ki67%CA125%Pelvic endometriosis%Abdominal wal endometriosis
目的：检测腹壁切口子宫内膜异位症患者病灶组织中Ki67的表达和血清CA125水平，探讨其临床意义。方法收集住院手术经病理检查证实为腹壁切口子宫内膜异位症患者38例（研究组），盆腔子宫内膜异位症患者57例（对照组），用免疫组化方法测定两组患者病灶组织中Ki67的表达，放射免疫法测定血清CA125水平，分析其临床资料并进行随访。结果研究组患者Ki67阳性率（52.6%）显著高于对照组（24.6%）（P＜0.05），两组Ki67阳性患者的血清CA125水平均显著高于阴性患者（均P＜0.05）。研究组无复发病例，而对照组复发率为21.4%（P＜0.05）。结论腹壁切口子宫内膜异位症的发病机制可能与盆腔子宫内膜异位症不同；子宫内膜异位症患者Ki67的表达与CA125水平存在一定的正相关。
目的：檢測腹壁切口子宮內膜異位癥患者病竈組織中Ki67的錶達和血清CA125水平，探討其臨床意義。方法收集住院手術經病理檢查證實為腹壁切口子宮內膜異位癥患者38例（研究組），盆腔子宮內膜異位癥患者57例（對照組），用免疫組化方法測定兩組患者病竈組織中Ki67的錶達，放射免疫法測定血清CA125水平，分析其臨床資料併進行隨訪。結果研究組患者Ki67暘性率（52.6%）顯著高于對照組（24.6%）（P＜0.05），兩組Ki67暘性患者的血清CA125水平均顯著高于陰性患者（均P＜0.05）。研究組無複髮病例，而對照組複髮率為21.4%（P＜0.05）。結論腹壁切口子宮內膜異位癥的髮病機製可能與盆腔子宮內膜異位癥不同；子宮內膜異位癥患者Ki67的錶達與CA125水平存在一定的正相關。
목적：검측복벽절구자궁내막이위증환자병조조직중Ki67적표체화혈청CA125수평，탐토기림상의의。방법수집주원수술경병리검사증실위복벽절구자궁내막이위증환자38례（연구조），분강자궁내막이위증환자57례（대조조），용면역조화방법측정량조환자병조조직중Ki67적표체，방사면역법측정혈청CA125수평，분석기림상자료병진행수방。결과연구조환자Ki67양성솔（52.6%）현저고우대조조（24.6%）（P＜0.05），량조Ki67양성환자적혈청CA125수평균현저고우음성환자（균P＜0.05）。연구조무복발병례，이대조조복발솔위21.4%（P＜0.05）。결론복벽절구자궁내막이위증적발병궤제가능여분강자궁내막이위증불동；자궁내막이위증환자Ki67적표체여CA125수평존재일정적정상관。
Objective To investigate Ki67 expression in abdominal incisional endometriosis and its significance. Methods Patients with endometriosis (EMS) admitted in Hangzhou First People's Hospital from January 2010 to December 2013 were en-rol ed in the study, including 57 cases with pelvic endometriosis and 38 cases with abdominal incisional endometriosis. The ex-pression of proliferating cel nuclear antigen (Ki67) in tissue was detected with immunohistochemical method and serum CA- 125 levels were measured with radioimmunoassay. Results Ki67 expression in abdominal wal endometriosis was significantly high-er than that in pelvic endometriosis (P<0.05). Serum CA125 levels in abdominal wal endometriosis was significantly lower than that in pelvic endometriosis (P<0.05). Serum CA125 was significantly different between groups of different Ki67 expression (P<0.05). Cumulative recurrence rate in abdominal wal endometriosis was significantly lower than that in pelvic endometriosis. CA125 level was higher in EMS with positive Ki67 expression than that in EMS with negative Ki67 expression. Conclusion Ki67 is differently expressed in abdominal incision and in pelvic endometriosis, suggesting that the pathogenesis of abdominal incision endometriosis and pelvic endometriosis may be different;and Ki67 expression may be related to relapse of pelvic endometriosis.
