CAJ | 학술논문

目的：评价骨碱性磷酸酶对儿童佝偻病早期诊断及疗效评价的临床价值，通过骨碱性磷酸酶的检测了解该地区儿童佝偻病的发病率。方法选择2013年1～12月来宝鸡市中心医院体检的2184例儿童，按年龄分成婴儿、幼儿、学龄前、学龄期4组，采集指血，采用北京中生金域诊断技术有限公司提供的骨源性碱性磷酸酶试剂盒检测末梢血中骨碱性磷酸酶水平。结果2184例受检儿童中，临床佝偻病（NBAP＞250 U／L）的检出率为10.1％，且年龄越小检出率越高；亚临床佝偻病（NBAP 200～250 U／L）的检出率为65.5％，说明宝鸡地区大部分儿童处于亚健康状态；春冬季检出率高于夏秋季；NBAP 检出率无性别差异。结论儿童为生长发育较快时期，易引起维生素 D 缺乏，儿童骨碱性磷酸酶活性检测对维生素 D 缺乏引起的佝偻病的早期诊断有重要的临床价值。预防应从围产期开始，及时检测儿童骨碱性磷酸酶水平，以便早诊断、早治疗。
목적：평개골감성린산매대인동구루병조기진단급료효평개적림상개치，통과골감성린산매적검측료해해지구인동구루병적발병솔。방법선택2013년1～12월래보계시중심의원체검적2184례인동，안년령분성영인、유인、학령전、학령기4조，채집지혈，채용북경중생금역진단기술유한공사제공적골원성감성린산매시제합검측말소혈중골감성린산매수평。결과2184례수검인동중，림상구루병（NBAP＞250 U／L）적검출솔위10.1％，차년령월소검출솔월고；아림상구루병（NBAP 200～250 U／L）적검출솔위65.5％，설명보계지구대부분인동처우아건강상태；춘동계검출솔고우하추계；NBAP 검출솔무성별차이。결론인동위생장발육교쾌시기，역인기유생소 D 결핍，인동골감성린산매활성검측대유생소 D 결핍인기적구루병적조기진단유중요적림상개치。예방응종위산기개시，급시검측인동골감성린산매수평，이편조진단、조치료。
Objective To evaluate the clinical value of bone alkaline phosphatase in early diagnosis and treatment effect of chil-dren′rickets and to understand the incidence rate of rickets in children in the local region by the detection of neonatal bone alkaline phosphatase(NBAP).Methods 2 184 children with physical examination in our hospital from January to December 2013 were se-lected and divided into the infants,young children,preschool and school-age children groups according to age.The finger blood was collected for detecting the bone alkaline phosphatase in the peripheral blood by the bone alkaline phosphatase reagent kit provided by Beijing Jinyu diagnosis technology Co.,Ltd.Results Among detected 2 184 children,the detection rate of clinical rickets(NBAP>250 U/L)was 10.1 %,moreover the smaller the age,the higher the detection rate;the detection rate of subclinical rickets(NBAP 200~250 U/L)was 65.5%,indicating that most children in Baoji region were in sub-health state;the detection rate in spring and winter was higher than that in summer and autumn;the detection rate of NBAP had no gender difference.Conclusion Children are in the rapid growth and development period,easy to suffer from vitamin D deficiency,the activity detection of NBAP has important clinical value in the early diagnosis of rickets caused by vitamin D deficiency.Prevention should begin from perinatal period and NBAP should be timely detected in order to conduct early diagnosis and early treatment.