CAJ | 학술논문

目的：了解鲍曼不动杆菌的临床分布及对抗菌药物的耐药性，为临床治疗鲍曼不动杆菌感染提供合理用药的依据。方法收集临床标本中分离出的162株鲍曼不动杆菌，对其分布情况以及16种抗菌药物的药敏结果进行统计分析。结果标本分布以痰液为主（75.3％）；ICU 病区检出率最高（49.3％），其中多重耐药菌占81.2％（65／80）；ICU 病区鲍曼不动杆菌多重耐药现象严重，对16种常用抗菌药物的耐药率明显高于非 ICU 病区，差异具有统计学意义（P ＜0.01），妥布霉素、阿米卡星和头孢哌酮／舒巴坦的耐药率相对较低。结论加强多重耐药菌株的监测和 ICU 病区的消毒隔离，对于预防和控制医院感染具有重要意义。
목적：료해포만불동간균적림상분포급대항균약물적내약성，위림상치료포만불동간균감염제공합리용약적의거。방법수집림상표본중분리출적162주포만불동간균，대기분포정황이급16충항균약물적약민결과진행통계분석。결과표본분포이담액위주（75.3％）；ICU 병구검출솔최고（49.3％），기중다중내약균점81.2％（65／80）；ICU 병구포만불동간균다중내약현상엄중，대16충상용항균약물적내약솔명현고우비 ICU 병구，차이구유통계학의의（P ＜0.01），타포매소、아미잡성화두포고동／서파탄적내약솔상대교저。결론가강다중내약균주적감측화 ICU 병구적소독격리，대우예방화공제의원감염구유중요의의。
Objective To understand the clinical distribution of Acinetobacter baumannii and its resistance to antibacterial drugs in order to provide reference for clinical rational drug use in the treatment of Acinetobacter baumannii infection.Methods 162 strains of Acinetobacter baumannii isolated from clinical specimens were collected and performed the statistical analysis on the dis-tribution and the sensitivity to 16 kinds of antibacterial drugs.Results The specimen distribution was dominated by sputum speci-mens(75.3%).The ICU ward had the highest detection rate(49.3%),in which,multidrug resistant strains accounted for 81.2%(65/80);the strains from ICU had the serious multidrug resistance,their resistance rates to 16 kinds of commonly used antibacterial drugs were significantly higher than those the strains isolated from other wards,the difference had statistical significance(P <0.01).The resistance rates of Acinetobacter baumannii to tobramycin,amikacin and cefperazone/sulbactam were relatively lower. Conclusion Strengthening the monitoring of multidrug resistant Acinetobacter baumannii strains and the sterilization and isolation of ICU ward has the important significance to prevent and control nosocomial infection.