国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
23期
3173-3175
,共3页
陈陆飞%吴坤海%刘琛%林鸿星
陳陸飛%吳坤海%劉琛%林鴻星
진륙비%오곤해%류침%림홍성
高胆红素血症%新生儿溶血症%直接抗人球蛋白试验%游离抗体试验%抗体释放试验
高膽紅素血癥%新生兒溶血癥%直接抗人毬蛋白試驗%遊離抗體試驗%抗體釋放試驗
고담홍소혈증%신생인용혈증%직접항인구단백시험%유리항체시험%항체석방시험
hyperbilirubinemia%hemolytic disease of newborns%direct antiglobulin test%free antibody test%antibody re-lease test
目的：分析高胆红素血症患儿新生儿溶血病（hemolytic disease of newborn，HDN）血清学检测结果并探讨与其相关因素之间的关系。方法对796例高胆红素血症患儿的血样进行新生儿溶血三项试验，并分析 HDN 阳性率与血型、送检日龄、血红蛋白水平及血清总胆红素值等因素的关系。结果796例高胆红素血症患儿中 HDN 患儿184例（23.12％），其中 ABO-HDN 176例，Rh-HDN 8例。796例患儿血样检测结果中游离试验阳性180例（22.61％），释放试验阳性184例（23.12％），直抗试验阳性140例（17.59％）。B 型血患儿 HDN 阳性率高于 A 型血患儿，差异有统计学意义（χ2＝10.30，P ＜0.05）。HDN 阳性率与送检日龄密切相关，且日龄越大阳性检出率越低，差异有统计学意义（P ＜0.05）。184例 HDN 阳性患儿血红蛋白水平及血清总胆红素值与 HDN 患儿差异有统计学意义（P ＜0.05）。结论高胆红素血症患儿 HDN 阳性率较高，应尽早进行溶血三项试验，并可结合血红蛋白水平及血清总胆红素值来提高 HDN 检出率。
目的：分析高膽紅素血癥患兒新生兒溶血病（hemolytic disease of newborn，HDN）血清學檢測結果併探討與其相關因素之間的關繫。方法對796例高膽紅素血癥患兒的血樣進行新生兒溶血三項試驗，併分析 HDN 暘性率與血型、送檢日齡、血紅蛋白水平及血清總膽紅素值等因素的關繫。結果796例高膽紅素血癥患兒中 HDN 患兒184例（23.12％），其中 ABO-HDN 176例，Rh-HDN 8例。796例患兒血樣檢測結果中遊離試驗暘性180例（22.61％），釋放試驗暘性184例（23.12％），直抗試驗暘性140例（17.59％）。B 型血患兒 HDN 暘性率高于 A 型血患兒，差異有統計學意義（χ2＝10.30，P ＜0.05）。HDN 暘性率與送檢日齡密切相關，且日齡越大暘性檢齣率越低，差異有統計學意義（P ＜0.05）。184例 HDN 暘性患兒血紅蛋白水平及血清總膽紅素值與 HDN 患兒差異有統計學意義（P ＜0.05）。結論高膽紅素血癥患兒 HDN 暘性率較高，應儘早進行溶血三項試驗，併可結閤血紅蛋白水平及血清總膽紅素值來提高 HDN 檢齣率。
목적：분석고담홍소혈증환인신생인용혈병（hemolytic disease of newborn，HDN）혈청학검측결과병탐토여기상관인소지간적관계。방법대796례고담홍소혈증환인적혈양진행신생인용혈삼항시험，병분석 HDN 양성솔여혈형、송검일령、혈홍단백수평급혈청총담홍소치등인소적관계。결과796례고담홍소혈증환인중 HDN 환인184례（23.12％），기중 ABO-HDN 176례，Rh-HDN 8례。796례환인혈양검측결과중유리시험양성180례（22.61％），석방시험양성184례（23.12％），직항시험양성140례（17.59％）。B 형혈환인 HDN 양성솔고우 A 형혈환인，차이유통계학의의（χ2＝10.30，P ＜0.05）。HDN 양성솔여송검일령밀절상관，차일령월대양성검출솔월저，차이유통계학의의（P ＜0.05）。184례 HDN 양성환인혈홍단백수평급혈청총담홍소치여 HDN 환인차이유통계학의의（P ＜0.05）。결론고담홍소혈증환인 HDN 양성솔교고，응진조진행용혈삼항시험，병가결합혈홍단백수평급혈청총담홍소치래제고 HDN 검출솔。
Objective To analyze the serological detection results of hemolytic disease of newborns(HDN)in neonatal hyperbil-irubinemia and to explore the relationship between serological results and related factors.Methods The neonatal hemolytic three i-tems test were performed on blood specimens of 796 cases of neonatal hyperbilirubinemia.The relationship between the positive rate of HDN with the related factors such as blood type,specimens collecting time,hemoglobin level and serum total bilirubin value was analyzed.Results Among 796 cases of hyperbilirubinemia,184 cases were HDN(23.12%),in which 796 cases were ABO-HDN and 8 cases were Rh-HDN.The direct free antibody test,antibody release test and direct antiglobulin test were positive in 180 cases (22.61%),184 cases(23.12%)and 140 cases(17.59%)respectively.The HDN positive rate of the newborns with B blood type was higher than that of the newborns with A blood type,the difference between them had statistical significance(χ2 = 10.304,P <0.05).The HDN positive rate was closely related with the specimen collection time,moreover,the greater the day age,the higher the HDN positive rate,the difference showing statistical significance(P <0.05).The hemoglobin level and serum total bilirubin val-ue had statistically significant difference between newborns with HDN and those without HDN(P <0.05).Conclusion The posi-tive rate of HDN is high in newborns with hyperbilirubinemia.The hemolytic three items test should be performed as early as possi-ble.Combining with the hemoglobin level and serum total bilirubin value can increase the HDN detection rate.
