CAJ | 학술논문

目的：本研究的目的是调查常见自身免疫性疾病患者血清25-羟维生素 D[25（OH）D]的水平状况，以及不同自身免疫性疾病中是否存在差异。方法本研究的调查对象为2012年1月至2013年4月来该院就诊的自身免疫性疾病患者共137例，其中风湿性关节炎（rheumatoid arthritis，RA）71例，系统性红斑狼疮（systemic lupus erythematosus，SLE）36例，干燥综合征（Sjogren syndrome，SS）16例和强直性脊柱炎（ankylosing spondylitis，AS）14例。使用罗氏电化学技术检测其血清25（OH）D 的水平，比较不同自身免疫性疾病患者25（OH）D 是否存在差异，同时统计分析不同种类疾病25（OH）D 水平正常、不足和缺乏的比例是否存在差异。结果不同自身免疫性疾病患者血清25（OH）D 水平之间差异有统计学意义（P ＝0.006），RA 组显著高于其他组；RA、SLE、SS 和 AS 组的25（OH）D 缺乏的比例分别为29.6％、52.8％、62.5％和57.1％，SLE、SS 和 AS 组显著高于 RA 组（P＜0.05）。结论常见自身免疫性疾病患者血清25（OH）D 缺乏比较普遍，需加强维生素 D 补充。
목적：본연구적목적시조사상견자신면역성질병환자혈청25-간유생소 D[25（OH）D]적수평상황，이급불동자신면역성질병중시부존재차이。방법본연구적조사대상위2012년1월지2013년4월래해원취진적자신면역성질병환자공137례，기중풍습성관절염（rheumatoid arthritis，RA）71례，계통성홍반랑창（systemic lupus erythematosus，SLE）36례，간조종합정（Sjogren syndrome，SS）16례화강직성척주염（ankylosing spondylitis，AS）14례。사용라씨전화학기술검측기혈청25（OH）D 적수평，비교불동자신면역성질병환자25（OH）D 시부존재차이，동시통계분석불동충류질병25（OH）D 수평정상、불족화결핍적비례시부존재차이。결과불동자신면역성질병환자혈청25（OH）D 수평지간차이유통계학의의（P ＝0.006），RA 조현저고우기타조；RA、SLE、SS 화 AS 조적25（OH）D 결핍적비례분별위29.6％、52.8％、62.5％화57.1％，SLE、SS 화 AS 조현저고우 RA 조（P＜0.05）。결론상견자신면역성질병환자혈청25（OH）D 결핍비교보편，수가강유생소 D 보충。
Objective To investigate the serum concentration of 25-hydroxyl vitamin D in the common autoimmune diseases and whether the differences of the 25-hydroxyl vitamin D level exist in different autoimmune diseases.Methods 137 cases of autoim-mune diseases,including 71 cases of rheumatoid arthritis(RA),36 cases of systemic lupus erythematosus(SLE),16 cases of Sjogren syndrome(SS)and 14 cases of ankylosing spondylitis(AS),in our hospital from January 2012 to April 2013 were selected as the re-spondents.The serum samples were collected for detecting the 25-hydroxyl vitamin D level by the electrochemiluminescence method and comparing the differences of the 25-hydroxyl vitamin D level among different autoimmune diseases.At the same time whether the differences in the proportion of the normal level,insufficiency and lack of 25-hydroxyl vitamin D exist among different kinds of disease.Results The serum 25-hydroxyl vitamin D concentration had statistically significant difference among the patients with dif-ferent autoimmune diseases(P =0.006),which in the RA group was significantly higher than that in the other groups;the propor-tion of 25-hydroxyl vitamin D insufficiency in RA,SLE,SS and AS were 29.6%,52.8%,62.5% and 57.1% respectively,which in the SLE,SS and AS groups was significantly higher than that in the RA group(P <0.05).Conclusion The 25-hydroxyl vitamin)D insufficiency is general in common autoimmune diseases,the vitamin D supplements needs to be strengthened.