CAJ | 학술논문

目的：评价神经节苷脂治疗新生儿缺氧缺血性脑病（HIE）的有效性及安全性。方法随机抽取2012‐12—2013‐12我院住院治疗的54例新生儿缺氧缺血性脑病患者作为研究对象，按照随机双盲对照原则分为对照组和观察组，对照组主要采取综合治疗，观察组在综合治疗的基础上以神经节苷脂治疗，治疗后观察2组患者新生儿行为神经评分，并比较2组患者NSE、S100B水平。结果2组患者NBNA评分在治疗第10天逐渐出现差异，观察组患者较对照组NBNA评分高，治疗第28天2组NBNA评分差异增大；观察组患者较对照组血清NSE、S100B水平高，2组比较差异有统计学意义（P＜0.05）。结论神经节苷脂治疗 H IE临床效果良好，且无不良反应，是一种安全有效的治疗方法。
목적：평개신경절감지치료신생인결양결혈성뇌병（HIE）적유효성급안전성。방법수궤추취2012‐12—2013‐12아원주원치료적54례신생인결양결혈성뇌병환자작위연구대상，안조수궤쌍맹대조원칙분위대조조화관찰조，대조조주요채취종합치료，관찰조재종합치료적기출상이신경절감지치료，치료후관찰2조환자신생인행위신경평분，병비교2조환자NSE、S100B수평。결과2조환자NBNA평분재치료제10천축점출현차이，관찰조환자교대조조NBNA평분고，치료제28천2조NBNA평분차이증대；관찰조환자교대조조혈청NSE、S100B수평고，2조비교차이유통계학의의（P＜0.05）。결론신경절감지치료 H IE림상효과량호，차무불량반응，시일충안전유효적치료방법。
Objective To study the efficiency and safety of gangliosides in the treatment of neonatal hypoxic‐ischemic en‐cephalopathy(HIE) ,so as to improve the clinical efficacy.Methods Fifty‐four cases of neonatal HIE in our hospital from Dec 2012 to Dec 2013 were selected as the study objects ,then divided them into observation group and control group by random double blind method.Comprehensive treatment was adopted in control group ,observation group was treated by gangliosides based on control group ,and nerve score ,NSE ,S1OOB level ,efficiency and safety of two groups after treatment were observed and compared.Results Differences of NBNA score in two groups had appeared gradually after treatment of 10 days ,of which observation group was higher than control group ;in the 28th day of treatment ,NBNA score difference increased ,serum NSE , S1OOB levels of observation group were higher than control group ,the differences between two groups were statistically signif‐icant ,P<0.05.Conclusion The efficacy of gangliosides in the treatment of neonatal HIE is obvious ,without adverse reac‐tions ,it’s a safe and effective treatment for neonatal HIE.