CAJ | 학술논문

目的：探讨帕罗西汀联合曲唑酮治疗抑郁症患者睡眠障碍的临床效果。方法回顾性分析我院门诊106例抑郁症患者的临床资料，根据治疗方法不同分为治疗组和对照组各53例，对照组患者给予帕罗西汀治疗，治疗组在对照组治疗基础上加用曲唑酮，比较2组治疗6周后临床疗效、睡眠质量以及不良反应发生情况。结果治疗6周后治疗组总有效率88.68％，对照组75.47％，2组比较差异有统计学意义（ P＜0.05）；治疗3周和6周后治疗组患者睡眠质量良好率均显著高于对照组（ P＜0.05）；治疗组总不良反应发生率15.09％，与对照组的18.88％比较，差异无统计学意义（ P＞0.05）。结论帕罗西汀联合曲唑酮治疗抑郁症睡眠障碍患者可显著提高睡眠质量，效果显著，且安全性高。
목적：탐토파라서정연합곡서동치료억욱증환자수면장애적림상효과。방법회고성분석아원문진106례억욱증환자적림상자료，근거치료방법불동분위치료조화대조조각53례，대조조환자급여파라서정치료，치료조재대조조치료기출상가용곡서동，비교2조치료6주후림상료효、수면질량이급불량반응발생정황。결과치료6주후치료조총유효솔88.68％，대조조75.47％，2조비교차이유통계학의의（ P＜0.05）；치료3주화6주후치료조환자수면질량량호솔균현저고우대조조（ P＜0.05）；치료조총불량반응발생솔15.09％，여대조조적18.88％비교，차이무통계학의의（ P＞0.05）。결론파라서정연합곡서동치료억욱증수면장애환자가현저제고수면질량，효과현저，차안전성고。
Objective To investigate the curative effect of paroxetine combined with trazodone in the treatment of depres‐sion in patients with disorders in sleep. Methods Clinical data of 106 cases of outpatients with depression in our hospital were retrospectively analyzed. According to the different treatment methods ,they were divided into the treatment group and the con‐trol group ,and 53 cases in each group. The control group was taken with paroxetine ,and the treatment group was treated by trazodone on the basis of the control group. The clinical efficacy ,sleep quality ,and adverse events of the two groups after 6 weeks were taken for comparison.Results After 6 weeks of treatment ,the total efficiency rate in the treatment group was 88.68% ,and 75.47% in the control group ,the difference was statistically significant , P< 0.05. After treatment of three weeks and six weeks ,the quality of sleep in the treatment group was significantly higher than patients in the control group ,P<0.05. The overall incidence of adverse reactions in the treatment group was 15.09% ,which was 18.88% in the treatment group ,the difference wasn’t significant ,P>0.05.Conclusion Paroxetine combined with trazodone in the treatment of depres‐sion in patients with sleep disorders can significantly improve sleep quality ,the clinical effect is significant and safe.