CAJ | 학술논문

目的：观察中药对膝骨性关节炎患者关节滑液及血清中透明质酸含量的影响，探究中药防治骨关节炎的现代机理。方法自2006年6月至2008年6月在我院就诊的膝骨性关节炎患者，选取其中30名肝肾亏虚型膝骨关节炎患者为治疗组，治疗前进行滑液及血清透明质酸浓度的检测，服用补肾中药独活寄生汤加减1个月后测血清透明质酸浓度，并监测半年及1年后透明质酸的浓度，把不同阶段检测的数据与20例正常组所得数据进行比较分析。结果治疗前 oa患者的血清 Ha 浓度明显升高，滑液中 Ha 浓度减低，与正常组相比P<0.01；治疗组的血清和滑液 Ha 浓度与治疗前比较均P<0.01,血清中的浓度减低，而滑液中的浓度出现了较明显的提高。结论中医补肾法能提高膝关节透明质酸的水平，同时降解血清中透明质酸，从而达到保护关节软骨延缓软骨退变的重要作用。
목적：관찰중약대슬골성관절염환자관절활액급혈청중투명질산함량적영향，탐구중약방치골관절염적현대궤리。방법자2006년6월지2008년6월재아원취진적슬골성관절염환자，선취기중30명간신우허형슬골관절염환자위치료조，치료전진행활액급혈청투명질산농도적검측，복용보신중약독활기생탕가감1개월후측혈청투명질산농도，병감측반년급1년후투명질산적농도，파불동계단검측적수거여20례정상조소득수거진행비교분석。결과치료전 oa환자적혈청 Ha 농도명현승고，활액중 Ha 농도감저，여정상조상비P<0.01；치료조적혈청화활액 Ha 농도여치료전비교균P<0.01,혈청중적농도감저，이활액중적농도출현료교명현적제고。결론중의보신법능제고슬관절투명질산적수평，동시강해혈청중투명질산，종이체도보호관절연골연완연골퇴변적중요작용。
Objective to observe the effect of Kidney-reinforcing therapy on patients with osteoarthritis of knee joint synovial fluid and serum hyaluronic acid level in research of influence, traditional chinese medicine for prevention and treatment of osteoarthritis of the modern mechanism. Methods from 2006 June to 2008 June in nan chang Hong du Hospital of traditional Chinese medicine treatment of patients with knee osteoarthritis, select one of 30 Gan-shen deficiency patients with knee osteoarthritis, first before treatment for synovial fluid and serum hyaluronic acid concentration detection, taking medicine du huo ji sheng decoction after one month, detected in half a year and after one year follow-up testing hyaluronic acid concentration, the different stages of testing data and from 20 normal cases obtained normal data for comparative analysis, in order to observe its changes. Results Before the treatment of OA patients with serum HA concentrations were significantly elevated in synovial fluid, to find reduced compared with the normal group P<0.01, the treatment group in the serum and synovial fluid concentrations of HA compared with before treatment P<0.01,the concentration in serum and synovial fluid concentrations in the lower, appeared obvious improvement.Conclusions Kidney-reinforcing therapy of traditional chinese medicine can mobilize endogenous hyaluronan, improves knee hyaluronic acid levels, while the degradation of serum hyaluronic acid concentration, and can keep the concentration of hyaluronic acid in lasting effect, so as to achieve the protection of joint cartilage to retard the prominent function of cartilage degeneration.