CAJ | 학술논문

目的：观察“肺通合剂”联合贝前列腺素钠对慢性阻塞性肺病相关性肺高压患者的影响。方法50例慢性阻塞性肺病急性期加重患者按数字表法随机分为两组。对照组采用西医常规治疗，同时每日口服贝前列腺素钠40ug 每日两次；治疗组在对照组基础上加用中药肺通合剂进行治疗，每日1剂分两次口服，两周后观察两组治疗前后临床疗效、肺动脉收缩压( PasP)、动脉血氧分压变化等。结果对照组临床总有效率64%，肺动脉收缩压下降率18.6%，二氧化碳分压下降率约11.7%；治疗组临床总有效率88%，肺动脉收缩压下降率约33%，组间相应各项比较差异均有统计学意义( p ＜0.05)；对照组及治疗组氧分压治疗后均较治疗前有明显提升，但两者比较差异无统计学意义(p >0.05)。结论在西医常规治疗及口服贝前列腺素钠基础上联合中药可以有效降低 PasP，改善患者缺氧症状，提升氧分压，无明显低血压的副作用，是治疗慢性阻塞性肺病合并肺高压的一种有效、经济的治疗方案。
목적：관찰“폐통합제”연합패전렬선소납대만성조새성폐병상관성폐고압환자적영향。방법50례만성조새성폐병급성기가중환자안수자표법수궤분위량조。대조조채용서의상규치료，동시매일구복패전렬선소납40ug 매일량차；치료조재대조조기출상가용중약폐통합제진행치료，매일1제분량차구복，량주후관찰량조치료전후림상료효、폐동맥수축압( PasP)、동맥혈양분압변화등。결과대조조림상총유효솔64%，폐동맥수축압하강솔18.6%，이양화탄분압하강솔약11.7%；치료조림상총유효솔88%，폐동맥수축압하강솔약33%，조간상응각항비교차이균유통계학의의( p ＜0.05)；대조조급치료조양분압치료후균교치료전유명현제승，단량자비교차이무통계학의의(p >0.05)。결론재서의상규치료급구복패전렬선소납기출상연합중약가이유효강저 PasP，개선환자결양증상，제승양분압，무명현저혈압적부작용，시치료만성조새성폐병합병폐고압적일충유효、경제적치료방안。
Objective to observe the effect of combination of fei tong mixture and beraprost sodium in the treatment of pulmonary hypertension associated with chronic obstructive pulmonary disease.Methods 50 cases of patients with chronic obstructive pulmonary disease during acute exacerbation period were randomly divided into two groups. the control group patients received routine treatment, with oral taken beraprost sodium in a dose of 40ug, twice a day. the treatment group patients were treated with traditional chinese medicine of fei tong mixture on the basis of the treatment in the control group, with oral taken 1 dose daily, twice a day. the clinical efficacy, pulmonary artery systolic pressure (PasP) and arterial oxygen partial pressure changes were observed in the two groups before and after treatment.Results in the control group, the total effective rate was 64%, and the reduction rate of pulmonary artery systolic pressure and the partial pressure of carbon dioxide was 18.6%and11.7%, respectively. While in the treatment group, the total effective rate was 88%, and the reduction rate of pulmonary artery systolic pressure was 33%, there was a statistically significant difference between two groups (P<0.05). the oxygen partial pressure in the control and treatment group after treatment were better improved than before treatment, but there was no statistically significant difference (p > 0.05).Conclusion routine treatment combined with traditional chinese medicine on the basis of oral taken beraprost sodium, can effectively reduce PasP, improve the symptoms of hypoxia, improve oxygen partial pressure, with no obvious adverse reactions. therefore, this kind of treatment is an effective and inexpensive way to treat chronic obstructive pulmonary disease complicated with pulmonary hypertension.