中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
23期
4293-4297
,共5页
胸膜肿瘤%间皮瘤%药物疗法%靶向治疗
胸膜腫瘤%間皮瘤%藥物療法%靶嚮治療
흉막종류%간피류%약물요법%파향치료
Pleural neoplasms%Mesothelioma%Drug therapy%Targeting therapy
恶性胸膜间皮瘤（MPM）是一种少见的，恶性程度高、病变广，早期诊断较为困难，病死率高，治疗效果差的疾病。在我国发病率仍呈上升趋势。内科治疗主要以化疗为主，培美曲塞联合顺铂是目前一线治疗的标准方案。对于复发的 MPM 患者，疾病难以控制，二线化疗方案选择性少，单药培美曲塞可作为二线治疗用药。近年来，靶向治疗成为肿瘤治疗的研究热点，MPM的靶向药物虽有一定效果，但临床仍未广泛使用，由于缺乏大量的多中心随机对照研究，仍需进一步证实。
噁性胸膜間皮瘤（MPM）是一種少見的，噁性程度高、病變廣，早期診斷較為睏難，病死率高，治療效果差的疾病。在我國髮病率仍呈上升趨勢。內科治療主要以化療為主，培美麯塞聯閤順鉑是目前一線治療的標準方案。對于複髮的 MPM 患者，疾病難以控製，二線化療方案選擇性少，單藥培美麯塞可作為二線治療用藥。近年來，靶嚮治療成為腫瘤治療的研究熱點，MPM的靶嚮藥物雖有一定效果，但臨床仍未廣汎使用，由于缺乏大量的多中心隨機對照研究，仍需進一步證實。
악성흉막간피류（MPM）시일충소견적，악성정도고、병변엄，조기진단교위곤난，병사솔고，치료효과차적질병。재아국발병솔잉정상승추세。내과치료주요이화료위주，배미곡새연합순박시목전일선치료적표준방안。대우복발적 MPM 환자，질병난이공제，이선화료방안선택성소，단약배미곡새가작위이선치료용약。근년래，파향치료성위종류치료적연구열점，MPM적파향약물수유일정효과，단림상잉미엄범사용，유우결핍대량적다중심수궤대조연구，잉수진일보증실。
Malignant pleural mesothelioma (MPM) is a rare, high malignant degree, wide lesion disease, and its early diagnosis is difficult, case fatality rate is high, and treatment effect is poor. The incidence is still increasing in China. Chemotherapy is the main approach, and the combination of cisplatin and pemetrexed is the front-line standard treatment. For patients with recurrent malignant pleuralmesothelioma, disease is difficult to control, second-line chemotherapy has less selectivity, pemetrexed can be used as second-line drugs. Recently, targeted therapy has become the focus in the tumor treatment, malignant pleuralmesothelioma targeted drugs have a little effect, but still do not have widely clinical application, because of the lack of a large number of multicenter randomized controlled study, the clinical effects still need to be confirmed by farther research.
