中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
23期
4244-4250
,共7页
刘平%魏子白%于俊岩%田向阳%常建兰%张宁宁%李璐璐%张蓉%张瑛%黄然欣%乔鲜丽%郭红亮
劉平%魏子白%于俊巖%田嚮暘%常建蘭%張寧寧%李璐璐%張蓉%張瑛%黃然訢%喬鮮麗%郭紅亮
류평%위자백%우준암%전향양%상건란%장저저%리로로%장용%장영%황연흔%교선려%곽홍량
肿瘤循环细胞%乳腺肿瘤%预后
腫瘤循環細胞%乳腺腫瘤%預後
종류순배세포%유선종류%예후
Neoplasm circulating cells%Breast neoplasms%Prognosis
目的:系统性评价CellSearch检测循环肿瘤细胞在转移性乳腺癌患者预后中的作用。方法检索 PubMed、EMbase、Cochrane图书馆、中国期刊全文数据库(CNKI)及中国生物医学文献数据库(CBM)等,收集CellSearch检测循环肿瘤细胞(CTCs)对转移性乳腺癌患者预后的研究。以无进展生存期(PFS)和总生期(OS)为观察终点,Review Manager 5.1进行Meta分析。结果19篇英文文献包含3710例转移性乳腺癌患者纳入荟萃分析,分析结果显示CTCs阳性组与肿瘤转移灶数目增加呈强相关(OR=1.53,95%CI:1.26~1.85)。与肿瘤原发灶HER2+(OR=1.15,95%CI:0.62~2.13),肿瘤分级(OR=1.68,95%CI:0.55~5.14),肿瘤治疗(OR=0.89,95%CI:0.72~1.11)无相关性。CTC阳性组较阴性组在PFS(HR=1.67,95% CI:1.44~1.92)、OS(HR=2.80,95%CI:2.32~3.37)上均有统计学意义(P<0.05),根据不同的标本采集时间进行亚组分析,CTC阳性组均比CTC阴性患者预后差。结论 CellSearch System检测CTCs用来预测转移性乳腺癌患者预后,其中,CTC阳性组是肿瘤的转移的风险因素,基线及治疗前CTC阳性组均预示转移性乳腺癌患者预后不良,敏感性分析和漏斗图分析结果提示该研究结果可信度高。
目的:繫統性評價CellSearch檢測循環腫瘤細胞在轉移性乳腺癌患者預後中的作用。方法檢索 PubMed、EMbase、Cochrane圖書館、中國期刊全文數據庫(CNKI)及中國生物醫學文獻數據庫(CBM)等,收集CellSearch檢測循環腫瘤細胞(CTCs)對轉移性乳腺癌患者預後的研究。以無進展生存期(PFS)和總生期(OS)為觀察終點,Review Manager 5.1進行Meta分析。結果19篇英文文獻包含3710例轉移性乳腺癌患者納入薈萃分析,分析結果顯示CTCs暘性組與腫瘤轉移竈數目增加呈彊相關(OR=1.53,95%CI:1.26~1.85)。與腫瘤原髮竈HER2+(OR=1.15,95%CI:0.62~2.13),腫瘤分級(OR=1.68,95%CI:0.55~5.14),腫瘤治療(OR=0.89,95%CI:0.72~1.11)無相關性。CTC暘性組較陰性組在PFS(HR=1.67,95% CI:1.44~1.92)、OS(HR=2.80,95%CI:2.32~3.37)上均有統計學意義(P<0.05),根據不同的標本採集時間進行亞組分析,CTC暘性組均比CTC陰性患者預後差。結論 CellSearch System檢測CTCs用來預測轉移性乳腺癌患者預後,其中,CTC暘性組是腫瘤的轉移的風險因素,基線及治療前CTC暘性組均預示轉移性乳腺癌患者預後不良,敏感性分析和漏鬥圖分析結果提示該研究結果可信度高。
목적:계통성평개CellSearch검측순배종류세포재전이성유선암환자예후중적작용。방법검색 PubMed、EMbase、Cochrane도서관、중국기간전문수거고(CNKI)급중국생물의학문헌수거고(CBM)등,수집CellSearch검측순배종류세포(CTCs)대전이성유선암환자예후적연구。이무진전생존기(PFS)화총생기(OS)위관찰종점,Review Manager 5.1진행Meta분석。결과19편영문문헌포함3710례전이성유선암환자납입회췌분석,분석결과현시CTCs양성조여종류전이조수목증가정강상관(OR=1.53,95%CI:1.26~1.85)。여종류원발조HER2+(OR=1.15,95%CI:0.62~2.13),종류분급(OR=1.68,95%CI:0.55~5.14),종류치료(OR=0.89,95%CI:0.72~1.11)무상관성。CTC양성조교음성조재PFS(HR=1.67,95% CI:1.44~1.92)、OS(HR=2.80,95%CI:2.32~3.37)상균유통계학의의(P<0.05),근거불동적표본채집시간진행아조분석,CTC양성조균비CTC음성환자예후차。결론 CellSearch System검측CTCs용래예측전이성유선암환자예후,기중,CTC양성조시종류적전이적풍험인소,기선급치료전CTC양성조균예시전이성유선암환자예후불량,민감성분석화루두도분석결과제시해연구결과가신도고。
ObjectiveThis analysis was undertaken to evaluate the prognostic role of CellSearch system-detected circulating tumor cell (CTC) in metastatic breast cancer. MethodsTrials using CellSearch system-detected CTC to predict the prognosis of patients with metastatic breast cancer were searched though the PubMed, EMbase, Cochrane library, China National Knowledge infrastructure (CNKI), and Chinese Biomedical Literature Database (CBM). Progression-free survival (PFS) and overall survival (OS) were main outcome measures. Review Manager 5.2.7 was used for this analysis. ResultsThe final pooling dataset had a total of 3 710 patients from 19 studies. CTCs positive group showed a significant correlation with the number of tumor metastases (OR=1.53, 95%CI: 1.26-1.85), rather than primary tumor HER2+ (OR=1.15, 95%CI: 0.62-2.13), tumor grade (OR=1.68, 95% CI: 0.55-5.14), and tumor treatment (OR=0.89, 95%CI: 0.72-1.11). The CTC positive group, as compared with the control group, demonstrated statistical significance in both PFS (HR=1.67, 95%CI: 1.44-1.92) and OS (HR=2.80, 95%CI: 2.32-3.37). Stratification by different sampling time showed poorer prognosis in the CTC positive group compared to the control group (P<0.05).ConclusionThe analysis reveals that CelSearch system-detected CTC predicts a poor prognosis of metastatic breast cancer and positive CTC may represent a risk factor for this metastasis. Sensitivity analysis and the funnel plots have validated the reliability of the combined estimates.