医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2014年
23期
372-373
,共2页
男性乳腺癌%诊断%治疗
男性乳腺癌%診斷%治療
남성유선암%진단%치료
目的：探讨男性乳腺癌的临床特点及诊治经验。方法对大同市第一人民医院自1999年7月至2012年2月收治的51例男性乳腺癌的临床特点，病理学特点，激素受体情况，随访资料进行分析。结果本组病例获得随访42例，9例失访，随访时间4-173个月，平均随访31.4个月。术后5年以上生存12例。死亡7例，2例因全身多处转移死亡。术后5年内生存36例，随访4--47个月均无瘤生存。术后出现远处转移的7例,有同侧锁骨上,肺部,脑部,肋骨,纵隔,颈部等。结论年龄、临床分期和淋巴结情况是影响生存率的独立影响因素，对于激素及其受体在男性乳腺癌患者中所发挥的作用仍需要进一步的研究。虽然男性乳腺癌患者的治疗方案与女性乳腺癌基本相同，但男性乳腺癌具有独特的生物学特性，特别是雄性激素在男性乳腺癌患者发病及疾病进展过程中的作用尚不清楚。男性乳腺癌的最佳治疗方案还需要根据大规模随机对照临床实验来确定。
目的：探討男性乳腺癌的臨床特點及診治經驗。方法對大同市第一人民醫院自1999年7月至2012年2月收治的51例男性乳腺癌的臨床特點，病理學特點，激素受體情況，隨訪資料進行分析。結果本組病例穫得隨訪42例，9例失訪，隨訪時間4-173箇月，平均隨訪31.4箇月。術後5年以上生存12例。死亡7例，2例因全身多處轉移死亡。術後5年內生存36例，隨訪4--47箇月均無瘤生存。術後齣現遠處轉移的7例,有同側鎖骨上,肺部,腦部,肋骨,縱隔,頸部等。結論年齡、臨床分期和淋巴結情況是影響生存率的獨立影響因素，對于激素及其受體在男性乳腺癌患者中所髮揮的作用仍需要進一步的研究。雖然男性乳腺癌患者的治療方案與女性乳腺癌基本相同，但男性乳腺癌具有獨特的生物學特性，特彆是雄性激素在男性乳腺癌患者髮病及疾病進展過程中的作用尚不清楚。男性乳腺癌的最佳治療方案還需要根據大規模隨機對照臨床實驗來確定。
목적：탐토남성유선암적림상특점급진치경험。방법대대동시제일인민의원자1999년7월지2012년2월수치적51례남성유선암적림상특점，병이학특점，격소수체정황，수방자료진행분석。결과본조병례획득수방42례，9례실방，수방시간4-173개월，평균수방31.4개월。술후5년이상생존12례。사망7례，2례인전신다처전이사망。술후5년내생존36례，수방4--47개월균무류생존。술후출현원처전이적7례,유동측쇄골상,폐부,뇌부,륵골,종격,경부등。결론년령、림상분기화림파결정황시영향생존솔적독립영향인소，대우격소급기수체재남성유선암환자중소발휘적작용잉수요진일보적연구。수연남성유선암환자적치료방안여녀성유선암기본상동，단남성유선암구유독특적생물학특성，특별시웅성격소재남성유선암환자발병급질병진전과정중적작용상불청초。남성유선암적최가치료방안환수요근거대규모수궤대조림상실험래학정。
This objectons is to investigate the clinical features of male breast cancer and treatment experience.Methods The First People’s Hospital of Da Tong from July 1999 to February 2012, 51 cases of male breast cancer treated clinical features, pathological features, hormone receptor situation, fol ow-up data for analysise. Results The patients were fol owed up 42 cases, 9 patients lost , fol ow-up time was 4-173 months, average 31.4 months.12 cases survived more than 5 years after the surgery. 7 died, 2 patients died because of systemic metastases.36 cases disease-free survived in the 5 years, were fol owed up 4-47 months. Postoperative distant metastasis in 7 patients, ipsilateral clavicle, lung, brain, ribs, mediastinum, neck and so on.Conclusion Age, clinical stage and lymph node is the independent factors of survival for hormone receptors in male breast cancer patients and their role in the further research is stil needed. Although the treatment of patients with male breast cancer and female breast cancer is similar, but male breast cancer has a unique biological characteristics, particularly it’s not clear that how the male hormone play its roles in male breast cancer incidence and disease progression in patients. The best treatment of male breast cancer also need large-scale randomized control ed clinical trials to determine.
