CAJ | 학술논문

目的：探讨乙型肝炎病毒相关肝癌患者血清白介素28B(IL-28B)表达及意义研究。方法选取慢性HBV感染的患者90例，作为研究组，另选取同期20例健康志愿者作为对照研究组，检测血清IL-28B及甲胎蛋白（AFP）值等指标。结果肝癌组IL-28B及AFP均较高，P<0.05，有统计学意义。IL-28B检测值与肝癌患者肿瘤数目有一定的关联，不同肿瘤数目组间比较差异有统计学意义，P＜0.05。结论结合AFP检测，可更加准确的诊断由乙型肝炎病毒导致的相关肝癌，值得临床检验继续深入探索。
목적：탐토을형간염병독상관간암환자혈청백개소28B(IL-28B)표체급의의연구。방법선취만성HBV감염적환자90례，작위연구조，령선취동기20례건강지원자작위대조연구조，검측혈청IL-28B급갑태단백（AFP）치등지표。결과간암조IL-28B급AFP균교고，P<0.05，유통계학의의。IL-28B검측치여간암환자종류수목유일정적관련，불동종류수목조간비교차이유통계학의의，P＜0.05。결론결합AFP검측，가경가준학적진단유을형간염병독도치적상관간암，치득림상검험계속심입탐색。
Objective: To investigate serum interleukin 28B (IL-28B) expression and significance in hepatitis B virus-related hepatocel ular carcinoma in patients. Methods: 90 patients with chronic HBV infection were selected as the study group, and another 20 healthy volunteers during the same period were also selected as the control group. The serum IL-28B and AFP values and other indicators were detected. Results: The IL-28B and AFP of the HCC group were statistical y significant higher than that of other groups(P<0.05). And there was statistical y significant association between the IL-28B value and the number of hepatocel ular carcinoma tumor in patients(P<0.05). Conclusion: The combination of AFP detection could more accurately improve the diagnosis of liver cancer caused by hepatitis B virus, worthy of clinical testing to continue in-depth exploration.