基层医学论坛
基層醫學論罈
기층의학론단
PUBLIC MEDICAL FORUM MAGAZINE
2014年
35期
4870-4871,4872
,共3页
解脲脲原体%生物群%耐药性%相关性%分析
解脲脲原體%生物群%耐藥性%相關性%分析
해뇨뇨원체%생물군%내약성%상관성%분석
Ureaplasma urealyticum%Biogroup%Drug resistance%Correlation%Analysis
目的:了解解脲脲原体(Ureaplasma urealyticum,Uu)生物群对常用抗菌药物的耐药程度及生物群与耐药性之间的关系,为指导临床合理使用抗生素提供依据。方法解脲脲原体生物群鉴定采用Uu核酸扩增荧光定量PCR技术,支原体鉴定及药敏试验采用支原体药敏试剂盒(培养法)。于573例支原体感染标本中鉴定出解脲脲原体,并对其进行生物分群及药敏试验,对实验结果进行统一分析。结果573例标本中259例Uu呈阳性,Uu的阳性率为45.20%,其中生物1群154例,阳性率为59.46%(154/259),生物2群63例,阳性率为24.32%(63/259),生物1群和生物2群共同感染27例,阳性率为10.42%(27/259),未知型15例,阳性率为5.79%(15/259)。 Uu对抗菌药物均产生了一定的耐药性。结论 Uu两个生物群的药敏检测结果比较分析显示:生物2群对强力霉素、司帕沙星、罗红霉素、克拉霉素、交沙霉素、壮观霉素、螺旋霉素的耐药性均比生物1群高(P<0.05)。 Uu生物群与耐药性有关,生物2群较为严重。
目的:瞭解解脲脲原體(Ureaplasma urealyticum,Uu)生物群對常用抗菌藥物的耐藥程度及生物群與耐藥性之間的關繫,為指導臨床閤理使用抗生素提供依據。方法解脲脲原體生物群鑒定採用Uu覈痠擴增熒光定量PCR技術,支原體鑒定及藥敏試驗採用支原體藥敏試劑盒(培養法)。于573例支原體感染標本中鑒定齣解脲脲原體,併對其進行生物分群及藥敏試驗,對實驗結果進行統一分析。結果573例標本中259例Uu呈暘性,Uu的暘性率為45.20%,其中生物1群154例,暘性率為59.46%(154/259),生物2群63例,暘性率為24.32%(63/259),生物1群和生物2群共同感染27例,暘性率為10.42%(27/259),未知型15例,暘性率為5.79%(15/259)。 Uu對抗菌藥物均產生瞭一定的耐藥性。結論 Uu兩箇生物群的藥敏檢測結果比較分析顯示:生物2群對彊力黴素、司帕沙星、囉紅黴素、剋拉黴素、交沙黴素、壯觀黴素、螺鏇黴素的耐藥性均比生物1群高(P<0.05)。 Uu生物群與耐藥性有關,生物2群較為嚴重。
목적:료해해뇨뇨원체(Ureaplasma urealyticum,Uu)생물군대상용항균약물적내약정도급생물군여내약성지간적관계,위지도림상합리사용항생소제공의거。방법해뇨뇨원체생물군감정채용Uu핵산확증형광정량PCR기술,지원체감정급약민시험채용지원체약민시제합(배양법)。우573례지원체감염표본중감정출해뇨뇨원체,병대기진행생물분군급약민시험,대실험결과진행통일분석。결과573례표본중259례Uu정양성,Uu적양성솔위45.20%,기중생물1군154례,양성솔위59.46%(154/259),생물2군63례,양성솔위24.32%(63/259),생물1군화생물2군공동감염27례,양성솔위10.42%(27/259),미지형15례,양성솔위5.79%(15/259)。 Uu대항균약물균산생료일정적내약성。결론 Uu량개생물군적약민검측결과비교분석현시:생물2군대강력매소、사파사성、라홍매소、극랍매소、교사매소、장관매소、라선매소적내약성균비생물1군고(P<0.05)。 Uu생물군여내약성유관,생물2군교위엄중。
ObjectiveTo investgate the common antimicrobial resistance level of Ureaplasma Urealyticum and the relationships between biovars and resistance for .the distribution of pathogens,and risk factor analysis in septicemia infection,for providing the basis for guiding clinical rational use of antibiotics.MethodsFluorescence quantitative PCR was applied to distinguishing Uu biovars.Identification and antimicrobial susceptibility testing mycoplasma susceptibility kits(culture method). 573 cases of mycoplasma infectionfor were tested and identified Uu were carried on the biological group and antimicrol susceptibility testing.Analyse the result of the experiment.ResultsIn a total of 573 cases,259 cases of Uu were positive.Uu positive rate wes 45.20%(259/573).Among them,biovar 1 accounted for 154, whose positive rate was 59.46%(154/259),and biovar 2 accounted for 63,whose positive rate was 24.32%(63/259). Common infection cases were 27 and positive rate was 10.42%(27/259).Unknown type cases were 15 and positive rate was 5.79%(15/259).Uu was resistant to 12 kinds of antimicrol agents.ConclusionThe analysis I combination of susceptibility tests showed biovar 1 was more sensitive to DOX、SPA、ROX、CLA、JOS、SPE and ASP than biovar 2(P﹤0.05) . Uu biovar is associated with the drug resistance and the resistance in biovar 2 is more severe.