CAJ | 학술논문

背景：家兔回肠代膀胱模型制作对麻醉要求较高，需要手术野清晰，术毕恢复迅速，麻醉药物及方法的选择不影响肠道平滑肌的蠕动。目的：比较水合氯醛和乌拉坦对家兔回肠代膀胱模型制作的麻醉效果。方法：18只家兔随机等分为乌拉坦组和水合氯醛组，分别用体积分数10%水合氯醛2 mL/kg和体积分数20%乌拉坦5 mL/kg实施耳缘静脉麻醉后，于原膀胱外1 cm处离断双输尿管，种植于回盲部10 cm处切取的15 cm肠段，建立回肠代膀胱模型。结果与结论：2组家兔麻醉后心率均较麻醉前出现明显下降(P≤0.05)，但2组间差异无显著性意义(P>0.05)。与水合氯醛组相比，乌拉坦组兔被麻醉的持续时间、苏醒时间过长，死亡率高。说明水合氯醛是适合家兔回肠代膀胱模型制作的安全长效的麻醉剂。
배경：가토회장대방광모형제작대마취요구교고，수요수술야청석，술필회복신속，마취약물급방법적선택불영향장도평활기적연동。목적：비교수합록철화오랍탄대가토회장대방광모형제작적마취효과。방법：18지가토수궤등분위오랍탄조화수합록철조，분별용체적분수10%수합록철2 mL/kg화체적분수20%오랍탄5 mL/kg실시이연정맥마취후，우원방광외1 cm처리단쌍수뇨관，충식우회맹부10 cm처절취적15 cm장단，건립회장대방광모형。결과여결론：2조가토마취후심솔균교마취전출현명현하강(P≤0.05)，단2조간차이무현저성의의(P>0.05)。여수합록철조상비，오랍탄조토피마취적지속시간、소성시간과장，사망솔고。설명수합록철시괄합가토회장대방광모형제작적안전장효적마취제。
BACKGROUND:The anesthesia process is required strict in establishing rabbit models of ileal neobladder. It is required for cleaning operation field, quick postoperative recovery, and the choice of anesthetics and anesthesia does not influence smooth muscle peristalsis. OBJECTIVE:To compare the anesthetic effects between urethane and chloral hydrate in rabbits with ileal neobladder. METHODS:Eighteen rabbits were randomly assigned to urethane and chloral hydrate groups, and were respectively anesthetized with 20% urethane 5 mL/kg and 10% chloral hydrate 2 mL/kg through the ear vein. Double ureter was dissociated at 1 cm outside original bladder, and 15 cm-intestine obtained from 10 cm of ileocecal junction was implanted so as to establish models of ileal neobladder. RESULTS AND CONCLUSION:Heart rates were significantly lower compared with these before anesthesia in al cases (P≤ 0.05), but no differences were detected between two groups (P > 0.05). Compared with the chloral hydrate group, the maintain time and recovery time were longer and the mortality rate was higher in the urethane group. Above data indicated that chloral hydrate is a safe long-acting anesthetic in establishing rabbit models of ileal neobladder.