CAJ | 학술논문

背景：原癌基因 c-Src 在调节高血压等心血管系统疾病中起着重要的作用，目前尚未看到有关运动干预影响主动脉血管内皮细胞c-Src的表达和活来调节高血压的研究。目的：观察有氧运动对自发性高血压大鼠主动脉血管内皮细胞c-Src mRNA表达和c-Src活性的影响。方法：8只雄性Wistar大鼠作为正常对照组，16只自发性高血压大鼠随机分为自发性高血压组8只，自发性高血压运动组8只。自发性高血压运动组每天进行90 min无负重有氧游泳运动，6 d/周，共8周；正常对照组和自发性高血压组大鼠不做游泳运动。每周测定大鼠血压1次，8周后，测定各组大鼠主动脉血管内皮细胞c-Src mRNA表达和c-Src活性。结果与结论：与自发性高血压组相比，自发性高血压运动组血压明显降低，主动脉血管内皮细胞c-Src mRNA表达和c-Src活性明显升高。与正常对照组相比，自发性高血压运动组大鼠主动脉血管内皮细胞c-Src活性和c-Src mRNA表达高于正常对照组和自发性高血压组(P <0.01)。结果提示有氧运动可以促进自发性高血压大鼠主动脉血管内皮细胞c-Src活性和c-Src mRNA表达的增加。
배경：원암기인 c-Src 재조절고혈압등심혈관계통질병중기착중요적작용，목전상미간도유관운동간예영향주동맥혈관내피세포c-Src적표체화활래조절고혈압적연구。목적：관찰유양운동대자발성고혈압대서주동맥혈관내피세포c-Src mRNA표체화c-Src활성적영향。방법：8지웅성Wistar대서작위정상대조조，16지자발성고혈압대서수궤분위자발성고혈압조8지，자발성고혈압운동조8지。자발성고혈압운동조매천진행90 min무부중유양유영운동，6 d/주，공8주；정상대조조화자발성고혈압조대서불주유영운동。매주측정대서혈압1차，8주후，측정각조대서주동맥혈관내피세포c-Src mRNA표체화c-Src활성。결과여결론：여자발성고혈압조상비，자발성고혈압운동조혈압명현강저，주동맥혈관내피세포c-Src mRNA표체화c-Src활성명현승고。여정상대조조상비，자발성고혈압운동조대서주동맥혈관내피세포c-Src활성화c-Src mRNA표체고우정상대조조화자발성고혈압조(P <0.01)。결과제시유양운동가이촉진자발성고혈압대서주동맥혈관내피세포c-Src활성화c-Src mRNA표체적증가。
BACKGROUND:Proto-oncogene c-Src plays an important role in regulating cardiovascular diseases such as hypertension. At present, there were no studies concerning exercise intervention effects on c-Src expression in aortic endothelial cels so as to regulate hypertension. OBJECTIVE: To observe the effects of aerobic exercise on c-Src mRNA expression and c-Src activity in the aorta blood vessel endothelial cels of spontaneous hypertensive rats. METHODS: A total of 8 male Wistar rats were considered as normal control group. Sixteen spontaneous hypertensive rats were randomly assigned to 8 rats as spontaneous hypertension group and 8 rats as spontaneous hypertension exercise group. Rats in the spontaneous hypertension exercise group carried on 90 minutes unloaded aerobic swimming every day, 6 days a week, for 8 weeks. The rats in the normal control group and spontaneous hypertension group did not swim. Blood pressure of rats was measured once a week. 8 weeks later, the c-Src mRNA expression and c-Src activity were determined in aortic vascular endothelial cels of rats in each group. RESULTS AND CONCLUSION: Compared with spontaneous hypertension group, blood pressure was lower, but c-Src mRNA expression and c-Src activity were significantly higher in the spontaneous hypertension exercise group. The c-Src activity and c-Src mRNA expression were higher in the spontaneous hypertension exercise group than normal control group and spontaneous hypertension group (P < 0.01). Results indicated that aerobic exercise can promote the increase in c-Src activity and c-Src mRNA expression in aortic endothelial cels of spontaneous hypertensive rats.