CAJ | 학술논문

目的：评价急性ST段抬高型心肌梗死（STEMI）患者行急诊PCI术时经血栓抽吸后冠脉应用替罗非班对梗死相关血管血流及临床预后的影响。方法将114例患者随机分为替罗非班组与对照组2组，比较2组TIMI血流、TMPG分级、心功能的改变、出血事件以及住院期间MACE事件率。结果替罗非班组术后TIMI血流及TMPG分级均优于对照组，LVEF明显高于对照组（P＜0．05），住院期间MACE低于对照组（P＜0．05），2组出血事件及LVEDD差异无统计学意义（P＞0．05）。结论在血栓抽吸后冠脉内应用替罗非班是处理冠状动脉内血栓安全、有效的方法，可减少慢血流或无血流的发生，改善心肌灌注及近期预后。
목적：평개급성ST단태고형심기경사（STEMI）환자행급진PCI술시경혈전추흡후관맥응용체라비반대경사상관혈관혈류급림상예후적영향。방법장114례환자수궤분위체라비반조여대조조2조，비교2조TIMI혈류、TMPG분급、심공능적개변、출혈사건이급주원기간MACE사건솔。결과체라비반조술후TIMI혈류급TMPG분급균우우대조조，LVEF명현고우대조조（P＜0．05），주원기간MACE저우대조조（P＜0．05），2조출혈사건급LVEDD차이무통계학의의（P＞0．05）。결론재혈전추흡후관맥내응용체라비반시처리관상동맥내혈전안전、유효적방법，가감소만혈류혹무혈류적발생，개선심기관주급근기예후。
Objective To evaluate the effect of tirofiban on blood flow and clinical prognosis of coronary intervention pa -tients after thrombus aspiration .Methods 114 cases were randomly divided into a tirofiban group and a control group .TIMI flow,TMPG classification,changes in heart function ,bleeding events and MACE events rate during hospital were compared be-tween the two groups .Results TIMI flow and TMPG grading of the tirofiban group were superior to the control group .LVEF was also significantly higher than the control group (P<0.05).MACE during hospital stay was lower than the control group (P<0.05),and bleeding events and LVEDD were similar between the two groups (P>0.05).Conclusion Intracoronary appli-cation of tirofiban after thrombus aspiration is safe and effective for the prevention of the slow -flow or non-flow of blood .It can improve myocardial perfusion and short-term prognosis .