CAJ | 학술논문

老年性聋是最常见的功能性致残性疾病，其发病原因和机制复杂，迄今尚未完全阐明，同时缺乏有效的治疗方法。迄今多数研究认为老年性聋是一种遗传因素与环境因素相互作用的复杂性疾病。其中人线粒体4977bp 缺失突变（大鼠为4834bp 缺失突变）被称为常见缺失突变，被认为与老年性聋密切相关。本文就线粒体相关老年性聋研究做一综述，介绍建立并利用相关研究模型，包括体内及体外模型对线粒体相关老年性聋进行发病机制及治疗方法研究的相关进展。
노년성롱시최상견적공능성치잔성질병，기발병원인화궤제복잡，흘금상미완전천명，동시결핍유효적치료방법。흘금다수연구인위노년성롱시일충유전인소여배경인소상호작용적복잡성질병。기중인선립체4977bp 결실돌변（대서위4834bp 결실돌변）피칭위상견결실돌변，피인위여노년성롱밀절상관。본문취선립체상관노년성롱연구주일종술，개소건립병이용상관연구모형，포괄체내급체외모형대선립체상관노년성롱진행발병궤제급치료방법연구적상관진전。
Presbycusis is the most common functional disabling disease, the pathogenesis of which has not been clarified up to now and there is lack of effective treatment method for this reason. It has been recently reported that it is a com-prehensive disease resulted from the interaction between the hereditary factors and environmental factors. The 4977bp deletion of presbycusis in human (The 4834bp deletion of mitochondrial DNA in rat) were called the Common Dele-tion, which were considered relating to the Presbycusis. The aim of this paper is to review the studying of the presbycusis associated with mitochondrial DNA deletion, present the progress in pathogenesis and therapy research( using the es-tablished in vivo and in vitro model) of this presbycusis .