CAJ | 학술논문

以磺酸丙基二乙醇基甲基铵内盐为引发剂开环丙交酯形成了含磺酸甜菜碱的聚乳酸(PLA-MPS),在确认了聚合物的分子结构后通过溶剂挥发法制备聚合物胶束.用动态光散射法(DLS)测定胶束的粒径及粒径分布,用荧光分光光度计测聚合物的临界胶束浓度.以疏水性化合物β-胡萝卜素(β-carotene)为模型药物研究胶束的载药性质,用双光束紫外分光光度计法测定载药量与包封率.结果表明,PLA-MPS胶束能够包载疏水性药物,PLA20-MPS 胶束的载药量与包封率最大分别为10％和60．3％之间.
이광산병기이을순기갑기안내염위인발제개배병교지형성료함광산첨채감적취유산(PLA-MPS),재학인료취합물적분자결구후통과용제휘발법제비취합물효속.용동태광산사법(DLS)측정효속적립경급립경분포,용형광분광광도계측취합물적림계효속농도.이소수성화합물β-호라복소(β-carotene)위모형약물연구효속적재약성질,용쌍광속자외분광광도계법측정재약량여포봉솔.결과표명,PLA-MPS효속능구포재소수성약물,PLA20-MPS 효속적재약량여포봉솔최대분별위10％화60．3％지간.
PLA-MPS were synthesized using L-lactide ring-opening polymerization by initiator sulfobetaines with two hydroxyl groups in ends.After the chemical structures of the polymers were confirmed,the polymers were prepared into micelles by solvent evaporation method.The critical micelle concentration (CMC)of the micelles was determined by fluorescence measurements on fluorescence spectrometer with pyrene as a probe.The sizes and sizes distribution of micelle were determined by dynamic light scattering (DLS).β-carotene was used as a model drug.The results showed that the polymers could form stable micelles and entrap the hydrophobic drug into their micelles.So,polylactide containing sulfobetaines may be a good candidate as a material for drug deliv-ery systems.