CAJ | 학술논문

目的：了解Mus81基因在中国汉族结直肠癌中的表达水平并分析其临床意义。方法收集43例手术切除的中国汉族结直肠癌及相应的癌旁组织标本，采用巢式荧光定量PCR技术检测标本中Mus81基因的表达水平，并分析Mus81基因表达与结直肠癌临床病理特征及常规肿瘤指标的相关性。结果 Mus81基因在结直肠癌中的表达水平低于相应的癌旁组织（114.6±68.0 vs 202.5±109.0，P<0.001）。Mus81基因在74.4%（32/43）的病例中表现为表达下调，且其表达下调与结直肠癌的远处转移（P=0.043）、TNM分期（P=0.022）及P53蛋白高表达（P=0.011）密切相关。结论 Mus81基因的表达水平在中国汉族结直肠癌中明显下调，且其表达下调与结直肠癌的转移潜能及进展相关，提示Mus81是中国汉族结直肠癌的一个潜在分子指标物。
목적：료해Mus81기인재중국한족결직장암중적표체수평병분석기림상의의。방법수집43례수술절제적중국한족결직장암급상응적암방조직표본，채용소식형광정량PCR기술검측표본중Mus81기인적표체수평，병분석Mus81기인표체여결직장암림상병리특정급상규종류지표적상관성。결과 Mus81기인재결직장암중적표체수평저우상응적암방조직（114.6±68.0 vs 202.5±109.0，P<0.001）。Mus81기인재74.4%（32/43）적병례중표현위표체하조，차기표체하조여결직장암적원처전이（P=0.043）、TNM분기（P=0.022）급P53단백고표체（P=0.011）밀절상관。결론 Mus81기인적표체수평재중국한족결직장암중명현하조，차기표체하조여결직장암적전이잠능급진전상관，제시Mus81시중국한족결직장암적일개잠재분자지표물。
Objective To explore the expression pattern of Mus81 gene in Chinese Han patients with colorectal cancer and analyze its correlation with the clinicopathological parameters and the tumor markers. Methods Mus81 expression was detected using nested quantitative real-time PCR in the colorectal cancer tissues and corresponding adjacent normal tissues from 43 Chinese Han patients. The correlations of Mus81 expression profile with the clinicopathological parameters and common tumor markers were evaluated. Results Mus81 expression level was significantly lower in the colorectal cancer tissues than in the corresponding adjacent normal tissues (114.6 ± 68.0 vs 202.5 ± 109.0, P<0.001). Of the 43 patients, 32 (74.4%) showed down-regulated Mus81 expression, which correlated significantly with distant metastasis (P=0.043), high TNM stage (P=0.022) and high P53 protein expression (P=0.011) of the tumor. Conclusion Down-regulation of Mus81 in colorectal cancer is correlated with tumor metastasis and progression, suggesting the value of Mus81 as a potential marker for colorectal cancer in Chinese Han pateints.