现代医药卫生
現代醫藥衛生
현대의약위생
MODERN MEDICINE HEALTH
2014年
23期
3548-3549,3551
,共3页
脂类/血液%冠心病%胆固醇%脂蛋白类,HDL%同型半胱氨酸
脂類/血液%冠心病%膽固醇%脂蛋白類,HDL%同型半胱氨痠
지류/혈액%관심병%담고순%지단백류,HDL%동형반광안산
Lipids/blood%Coronary disease%Cholesterol%Lipoproteins,HDL%Homocysteine
目的:探讨血清同型半胱氨酸(Hcy)及血脂水平与冠状动脉粥样硬化性心脏病(CHD)之间的关系。方法选择2013年1月至2014年4月在该院心内科住院的204例CHD患者为CHD组,其中中青年(36~<60岁)87例,老年(60~88岁)117例;同时选择在该院健康体检者122例为对照组,其中中青年(39~<60岁)52例,老年(60~83岁)70例。分别检测两组受试者血清Hcy水平,三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白AⅠ(apoAⅠ)、apoB、脂蛋白(a)[Lp(a)]水平,并进行比较与分析。结果两组老年Hcy水平显著高于中青年,且CHD组不同年龄的Hcy水平显著高于对照组,差异均有统计学意义(P<0.05);CHD组患者的Hcy、TG、Lp(a)水平显著高于对照组,apo AⅠ水平显著低于对照组,差异均有统计学意义(P<0.05),而两组之间TC、HDL-C、LDL-C、apoB水平比较,差异均无统计学意义(P>0.05)。结论 Hcy水平与年龄有关,是CHD的独立危险因子,其与血脂指标联合检测,对CHD患者的诊断、治疗及预后具有重要临床意义。
目的:探討血清同型半胱氨痠(Hcy)及血脂水平與冠狀動脈粥樣硬化性心髒病(CHD)之間的關繫。方法選擇2013年1月至2014年4月在該院心內科住院的204例CHD患者為CHD組,其中中青年(36~<60歲)87例,老年(60~88歲)117例;同時選擇在該院健康體檢者122例為對照組,其中中青年(39~<60歲)52例,老年(60~83歲)70例。分彆檢測兩組受試者血清Hcy水平,三酰甘油(TG)、總膽固醇(TC)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)、載脂蛋白AⅠ(apoAⅠ)、apoB、脂蛋白(a)[Lp(a)]水平,併進行比較與分析。結果兩組老年Hcy水平顯著高于中青年,且CHD組不同年齡的Hcy水平顯著高于對照組,差異均有統計學意義(P<0.05);CHD組患者的Hcy、TG、Lp(a)水平顯著高于對照組,apo AⅠ水平顯著低于對照組,差異均有統計學意義(P<0.05),而兩組之間TC、HDL-C、LDL-C、apoB水平比較,差異均無統計學意義(P>0.05)。結論 Hcy水平與年齡有關,是CHD的獨立危險因子,其與血脂指標聯閤檢測,對CHD患者的診斷、治療及預後具有重要臨床意義。
목적:탐토혈청동형반광안산(Hcy)급혈지수평여관상동맥죽양경화성심장병(CHD)지간적관계。방법선택2013년1월지2014년4월재해원심내과주원적204례CHD환자위CHD조,기중중청년(36~<60세)87례,노년(60~88세)117례;동시선택재해원건강체검자122례위대조조,기중중청년(39~<60세)52례,노년(60~83세)70례。분별검측량조수시자혈청Hcy수평,삼선감유(TG)、총담고순(TC)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)、재지단백AⅠ(apoAⅠ)、apoB、지단백(a)[Lp(a)]수평,병진행비교여분석。결과량조노년Hcy수평현저고우중청년,차CHD조불동년령적Hcy수평현저고우대조조,차이균유통계학의의(P<0.05);CHD조환자적Hcy、TG、Lp(a)수평현저고우대조조,apo AⅠ수평현저저우대조조,차이균유통계학의의(P<0.05),이량조지간TC、HDL-C、LDL-C、apoB수평비교,차이균무통계학의의(P>0.05)。결론 Hcy수평여년령유관,시CHD적독립위험인자,기여혈지지표연합검측,대CHD환자적진단、치료급예후구유중요림상의의。
Objective To explore the relationship between levels of serum homocysteine (Hcy),blood lipid and coronary heart disease (CHD). Methods A total of 204 patients with coronary heart disease patients was selceted as the CHD group ,in-cluding 87 young and middle-aged patients(36-<60 years old) and 117 aged patients(60-88 years old),meanwhile,another 122 healthy people were deem as the control group including 52 youths (39-60 years old) and the middle-aged and 70 aged people (60-83 years old), the levels of Hcy TG,TC,HDL-C,LDL-C,apoAⅠ,apoB,Lp(a) of the two groups were detected and com-pared. Results Hcy levels of the two aged groups were significantly higher than that of the young and middle-aged. Hcy level in different ages in CHD group was significantly higher than that of the control group (P<0.05). Hcy,TG,Lp(a) were significantly high-er than those of the control group,while apoAⅠwas significantly lower than the control group (P<0.05). TC,HDL-C,LDL-C and apo B levels between the two groups had no significant difference(P>0.05). Conclusions Hcy level is associated with age,who is one of independent risk factors for coronary heart disease;meanwhile,the combined inspection of CHD and blood lipids is bene-fit for the diagnosis,treatment and prognosis of great clinical significance.