CAJ | 학술논문

α放射核素在内照射时具有极强的细胞毒性，对肿瘤细胞具有较强的杀灭作用，而其短射程对正常组织影响较小，因此α放射核素类药物是放射性药物研究的重要领域和研究热点之一。α放射核素类药物的生产和研究关键在于核素的选择、高纯度核素的稳定可靠供应、核素载体及合适的体内动力学。目前国内外研究比较活跃的α放射核素主要包括223 Ra、225 Ac、213 Bi、211 At、212 Bi、149 Tb和227 Th等。本文主要介绍了以上核素的来源制备及用于肿瘤靶向治疗的最新进展，对存在的问题、现状及临床应用前景进行了简要的探讨。
α방사핵소재내조사시구유겁강적세포독성，대종류세포구유교강적살멸작용，이기단사정대정상조직영향교소，인차α방사핵소류약물시방사성약물연구적중요영역화연구열점지일。α방사핵소류약물적생산화연구관건재우핵소적선택、고순도핵소적은정가고공응、핵소재체급합괄적체내동역학。목전국내외연구비교활약적α방사핵소주요포괄223 Ra、225 Ac、213 Bi、211 At、212 Bi、149 Tb화227 Th등。본문주요개소료이상핵소적래원제비급용우종류파향치료적최신진전，대존재적문제、현상급림상응용전경진행료간요적탐토。
Alpha‐emitting radionuclides provide effective cell‐killing properties in vivo and have been shown to be effective in cancer treatment .Its short‐range make little effect on normal tissues ,thus alpha‐emitting radionuclides drugs is one of the important research focus areas and radiopharmaceutical research .T he excellent nature of the radi‐onuclide (right half life ,ray energy ,etc .) ,stable supply of high purity nuclides ,suit‐able radionuclide carrier base and excellent kinetics in vivo are necessary to the produc‐tion and research of alpha‐emitting radionuclides .At present ,the alpha‐emitting radio‐nuclidesinclude223Ra,225Ac,213Bi,211At,212Bi,149Tband227Thwereinvestagated.The preparation and sources of the above radionuclides and the latest developments for targe‐ted cancer therapy were described .The existing problems ,status and clinical applica‐tion were briefly discussed .