CAJ | 학술논문

采用还原碘化法合成11CH3I ，固相法合成11C‐MET ，HPLC分析产品放化纯度，并合成11CH3OH和11CH3I ，利用HPLC分析验证11C‐MET中杂质的成分，探讨溶解前体的NaOH浓度和有机溶剂用量对11C‐MET质量的影响。结果表明，先用0.1 mL 2 mol／L NaOH溶解前体，再与0.1 mL无水乙醇混匀后装入C18柱，可以提高11 C‐M ET的产率及放化纯度。
채용환원전화법합성11CH3I ，고상법합성11C‐MET ，HPLC분석산품방화순도，병합성11CH3OH화11CH3I ，이용HPLC분석험증11C‐MET중잡질적성분，탐토용해전체적NaOH농도화유궤용제용량대11C‐MET질량적영향。결과표명，선용0.1 mL 2 mol／L NaOH용해전체，재여0.1 mL무수을순혼균후장입C18주，가이제고11 C‐M ET적산솔급방화순도。
11C‐MET was synthesized by the solid phase reaction of 11CH3I and precursor L‐homocysteine ,and the radiochemical purity of 11C‐MET was analyzed by HPLC ,11C‐methanol and 11C‐methyl iodide were prepared and analyzed ,respectively .The primary impurity of the product were analyzed . The influence on the quality of product was investigated by changing the concentration of sodium hydroxide solution and the solvent of dissolving precursor .The results showed that 11C‐MET with higher yield and good radiochemical purity would obtain by using 0.1 mL 2 mol/L NaOH to dissolve the pre‐cursor ,then injecting it into the C18 column after blending 0.1 mL ethanol .