海南医学
海南醫學
해남의학
HAINAN MEDICAL JOURNAL
2014年
23期
3486-3488
,共3页
原发性高血压%N末端脑钠肽前体%淋巴细胞亚群
原髮性高血壓%N末耑腦鈉肽前體%淋巴細胞亞群
원발성고혈압%N말단뇌납태전체%림파세포아군
Essential hypertension%N-terminal pro-brain natriuretic peptide (NT-proBNP)%Lymphocyte sub-population
目的：探讨原发性高血压(EH)患者N末端脑钠肽前体(NT-proBNP)及淋巴细胞亚群等指标变化情况。方法328例高血压确诊患者按照分级标准进行分组，其中EH1级组115例，EH2级组109例，EH3级组104例；以120例同期健康体检者作为对照组。采用电化学发光免疫分析测定NT-proBNP水平和流式细胞仪分析CD3+、CD4+、CD8+、CD19+水平，组间进行比较。结果高血压组血清中NT-proBNP、CD4+/CD8+、CD19+水平较健康对照组明显升高（P<0.05），其中EH3级组升高最显著；CD3+、CD4+、CD8+细胞明显低于正常对照组(P<0.05)，EH3级组降低最显著。NT-proBNP水平与CD3+、CD4+、CD8+等指标均呈显著负相关(r=-0.951，r=-0.973，r=-0.955；P均<0.01），与CD19+细胞（B细胞）、CD4+/CD8+呈显著正相关(r=0.934，r=0.98；P均<0.01)。结论 EH患者的血压的临床分级与NT-proBNP、CD3+、CD4+、CD8+、CD19+的水平密切相关，并可能参与EH的病理生理过程。
目的：探討原髮性高血壓(EH)患者N末耑腦鈉肽前體(NT-proBNP)及淋巴細胞亞群等指標變化情況。方法328例高血壓確診患者按照分級標準進行分組，其中EH1級組115例，EH2級組109例，EH3級組104例；以120例同期健康體檢者作為對照組。採用電化學髮光免疫分析測定NT-proBNP水平和流式細胞儀分析CD3+、CD4+、CD8+、CD19+水平，組間進行比較。結果高血壓組血清中NT-proBNP、CD4+/CD8+、CD19+水平較健康對照組明顯升高（P<0.05），其中EH3級組升高最顯著；CD3+、CD4+、CD8+細胞明顯低于正常對照組(P<0.05)，EH3級組降低最顯著。NT-proBNP水平與CD3+、CD4+、CD8+等指標均呈顯著負相關(r=-0.951，r=-0.973，r=-0.955；P均<0.01），與CD19+細胞（B細胞）、CD4+/CD8+呈顯著正相關(r=0.934，r=0.98；P均<0.01)。結論 EH患者的血壓的臨床分級與NT-proBNP、CD3+、CD4+、CD8+、CD19+的水平密切相關，併可能參與EH的病理生理過程。
목적：탐토원발성고혈압(EH)환자N말단뇌납태전체(NT-proBNP)급림파세포아군등지표변화정황。방법328례고혈압학진환자안조분급표준진행분조，기중EH1급조115례，EH2급조109례，EH3급조104례；이120례동기건강체검자작위대조조。채용전화학발광면역분석측정NT-proBNP수평화류식세포의분석CD3+、CD4+、CD8+、CD19+수평，조간진행비교。결과고혈압조혈청중NT-proBNP、CD4+/CD8+、CD19+수평교건강대조조명현승고（P<0.05），기중EH3급조승고최현저；CD3+、CD4+、CD8+세포명현저우정상대조조(P<0.05)，EH3급조강저최현저。NT-proBNP수평여CD3+、CD4+、CD8+등지표균정현저부상관(r=-0.951，r=-0.973，r=-0.955；P균<0.01），여CD19+세포（B세포）、CD4+/CD8+정현저정상관(r=0.934，r=0.98；P균<0.01)。결론 EH환자적혈압적림상분급여NT-proBNP、CD3+、CD4+、CD8+、CD19+적수평밀절상관，병가능삼여EH적병리생리과정。
Objective To study the change of N-terminal pro-brain natriuretic peptide and lymphocyte sub-population in essential hypertensive patients. Methods Totally 328 hypertensive patients were divided into three groups according to the standard of classification:grade 1 hypertensive (115 patients), grade 2 hypertensive (109 pa-tients) and grade 3 hypertensive (104 patients). As the same time 120 normal controls were enrolled as control group. CD3+、CD4+、CD8+、CD19+level and serum NT-proBNP concentration were measured by flow cytometry and electroche-miluminescence immunoassay (ECLIA) . Results NT-ptoBNP, CD4/CD8 and CD19+ levels in 328 patients with EH were significantly higher than those in the controls (P<0.05) and they were increased with the increases of blood pres-sure, but CD3+, CD4+and CD8+levels were significantly lower (P<0.05) than the control and they were decreased with the increases of blood pressure. NT-proBNP level was negatively correlated with CD3+, CD4+ and CD8+ (r=-0.951, <br> r=-0.973, r=-0.955;P<0.01), and was positively correlated with CD19+ and CD4+/CD8+ (r=0.934, r=0.98; P<0.01). Conclusion NT-proBNP, CD3+, CD4+, CD8+ and CD19+were closely correlated with EH stage and probably in-volved in the pathophysiological process of EH.
