CAJ | 학술논문

目的：探讨乳腺浸润性导管癌组织中间隙连接蛋白43(Cx43)及上皮性钙黏蛋白(E-cad)表达中的相关性。方法采用Elivision免疫组织化学法对89例乳腺侵润性导管癌组织及48例分区组织的Cx43与E-cad检测。结果乳腺浸润性导管癌的肿瘤区、交界区和远癌区的Cx43和E-cad蛋白表达具有较好的一致性(γ=0.460,P<0.01)；在肿瘤区两者同时为阴性表达时,淋巴结转移率最高。结论 Cx43和E-cad在乳腺浸润性导管癌发生和发展过程中具有一定的协同作用,与其发生浸润转移有关。
목적：탐토유선침윤성도관암조직중간극련접단백43(Cx43)급상피성개점단백(E-cad)표체중적상관성。방법채용Elivision면역조직화학법대89례유선침윤성도관암조직급48례분구조직적Cx43여E-cad검측。결과유선침윤성도관암적종류구、교계구화원암구적Cx43화E-cad단백표체구유교호적일치성(γ=0.460,P<0.01)；재종류구량자동시위음성표체시,림파결전이솔최고。결론 Cx43화E-cad재유선침윤성도관암발생화발전과정중구유일정적협동작용,여기발생침윤전이유관。
Objective To explore the correlation of Connexion43(Cx43),E-cadherin(E-cad)in breast infiltrating ductal carcinoma tis-sue. Methods The expressions of Cx43 and E-cad proteins were detected in 89 cases breast infiltrating ductal carcinoma tissue,48 cases partition groups. by immunohistochemistry Elivision method. Results The expressions of Cx43 and E-cad has a better consistency in the tumor area,the border area and far cancer area of breast infiltrating ductal carcinoma. For both the negative expression in tumor area same time,the rate of lymph node metastasis was highest. Conclusion Cx43 and E-cad in breast invasive ductal carcinoma has a certain synergy in the process of the occurrence and development,which related to its metastasis occurred.