CAJ | 학술논문

目的：探讨老年缺血性脑卒中患者颈动脉斑块性质与血脂、细胞纤维结合蛋白以及同型半胱氨酸水平的关系。方法：选取100例颈动脉斑块伴缺血性脑卒中老年患者为研究组，并且选取同期健康体检的100例对象为对照组，测定2组血脂、血细胞纤维结合蛋白和同型半胱氨酸水平。结果：研究组的胆固醇、低密度脂蛋白胆固醇、细胞纤维结合蛋白及同型半胱氨酸含量均高于对照组（t＝6．936、13．260、13．585和13．347，P均＜0．001）。易损斑块患者的胆固醇、低密度脂蛋白胆固醇、细胞纤维结合蛋白及同型半胱氨酸含量较稳定斑块患者均升高（t＝6．204、3．112、7．438和6．961，P均＜0．05）。结论：细胞纤维结合蛋白、同型半胱氨酸水平升高和血脂异常在老年缺血性脑卒中的发生中具有一定的作用，且不同性质颈动脉斑块可能与该病的发生发展有关。
목적：탐토노년결혈성뇌졸중환자경동맥반괴성질여혈지、세포섬유결합단백이급동형반광안산수평적관계。방법：선취100례경동맥반괴반결혈성뇌졸중노년환자위연구조，병차선취동기건강체검적100례대상위대조조，측정2조혈지、혈세포섬유결합단백화동형반광안산수평。결과：연구조적담고순、저밀도지단백담고순、세포섬유결합단백급동형반광안산함량균고우대조조（t＝6．936、13．260、13．585화13．347，P균＜0．001）。역손반괴환자적담고순、저밀도지단백담고순、세포섬유결합단백급동형반광안산함량교은정반괴환자균승고（t＝6．204、3．112、7．438화6．961，P균＜0．05）。결론：세포섬유결합단백、동형반광안산수평승고화혈지이상재노년결혈성뇌졸중적발생중구유일정적작용，차불동성질경동맥반괴가능여해병적발생발전유관。
Aim:To investigate the relationship between carotid artery plaque and blood lipids , homocysteine ( Hcy) level, cellular fibronectin(c-Fn) in elderly patients with ischemic stroke.Methods:A total of 100 elderly patients with is-chemic stroke and arotid plaques were selected as the study group , and 100 cases of healthy subjects were used as the con-trol group.The lipid, c-Fn and Hcy levels were measured .Results: The TC, LDL-C, c-Fn, and Hcy levels in study group were significantly higher than that in control group (t=6.936, 13.260, 13.585, 13.347,P<0.001).The TC, LDL-C, c-Fn, and Hcy levels in vulnerable plaque group were significantly higher than stabilize plaque group ( t=6 .204 , 3.112, 7.438, 6.961,P<0.05).Conclusion: In elderly patients with carotid plaques and ischemic stroke , lipids, c-Fn, and Hcy are different from ordinary people .