CAJ | 학술논문

目的：研究帕金森病（ PD）患者认知功能障碍的发生率、临床特点及其相关影响因素。方法：应用蒙特利尔认知评估（MoCA）量表对52例PD患者（PD组）和58例健康对象（对照组）进行评定，探讨PD组患者认知功能障碍的发生率、临床特点及PD患者认知功能障碍与年龄、病程、H-Y分级、UPDRS评分的关系。结果：PD组Mo-CA评分（20．28±4．16）低于对照组（26．28±3．61）（t ＝8．036，P ＜0．001），PD 组患者认知功能障碍发生率（57．7％，30例）高于对照组（10．3％，6例）（χ2＝19．200，P＜0．001）。 PD患者认知功能障碍的主要特点表现为注意与集中、执行功能、延迟回忆、语言、视结构技能、抽象思维和定向力等下降。 Logistic回归分析显示PD组认知功能障碍与患者病情严重程度（H-Y分级）、病程、UPDRS（第1部分）评分、UPDRS（第2部分）评分有关（OR：5．464，6．172，1．138，1．305；95％CI：1．915～10．136，0．068～0．872，1．017～1．358，1．316～11．014）。结论：PD患者认知功能障碍发生率高，临床表现多样，其与病程、病情轻重、URPDS评分有关。
목적：연구파금삼병（ PD）환자인지공능장애적발생솔、림상특점급기상관영향인소。방법：응용몽특리이인지평고（MoCA）량표대52례PD환자（PD조）화58례건강대상（대조조）진행평정，탐토PD조환자인지공능장애적발생솔、림상특점급PD환자인지공능장애여년령、병정、H-Y분급、UPDRS평분적관계。결과：PD조Mo-CA평분（20．28±4．16）저우대조조（26．28±3．61）（t ＝8．036，P ＜0．001），PD 조환자인지공능장애발생솔（57．7％，30례）고우대조조（10．3％，6례）（χ2＝19．200，P＜0．001）。 PD환자인지공능장애적주요특점표현위주의여집중、집행공능、연지회억、어언、시결구기능、추상사유화정향력등하강。 Logistic회귀분석현시PD조인지공능장애여환자병정엄중정도（H-Y분급）、병정、UPDRS（제1부분）평분、UPDRS（제2부분）평분유관（OR：5．464，6．172，1．138，1．305；95％CI：1．915～10．136，0．068～0．872，1．017～1．358，1．316～11．014）。결론：PD환자인지공능장애발생솔고，림상표현다양，기여병정、병정경중、URPDS평분유관。
Aim:To study the incidence , clinical characteristics and related factors of cognitive dysfunction in Parkin-son′s disease(PD).Methods:A total of 52 patients with Parkinson′s disease (PD group) and 58 healthy patients (nor-mal group) were assessed by Montreal cognitive assessment (MoCA) scale,to study the incidence of cognitive dysfunction , clinical characteristics in PD patients and the relationship between the PD patients with cognitive dysfunction and age , du-ration, Hoehn-Yahr grade, UPDRS score.Results:The MoCA score in PD group was lower than that in normal group (t=8.036,P<0.001), the incidence of cognitive dysfunction was 57.7% in the PD group(χ2 =19.200,P<0.001).The main features of cognitive dysfunction in PD patients showed attention and concentration , executive functions , memory, de-layed recall, language skills, visual ability, abstract thinking and ability of orientation , retardation, etc.Logistic regression analysis showed that cognitive dysfunction in PD group was positively related with the severity of disease condition ( H-Y classification), duration, UPDRS (Part Ⅰ) score and UPDRS (Part Ⅱ) score(OR:5.464,6.172,1.138,1.305;95%CI:1.915-10.136,0.068-0.872,1.017-1.358,1.316-11.014).Conclusion: The incidence of cognitive dysfunc-tion in PD patients is high .There are many forms of clinical manifestations , and the extent of these manifestations is corre-lated with disease duration , severity and UPDRS score .