CAJ | 학술논문

目的：考察2-甲氧基雌二醇（2-ME）纳米混悬剂在肺癌荷瘤小鼠体内组织的分布特征。方法：70只昆明小鼠制作Lewis肺癌荷瘤鼠模型后随机分为2组，实验组小鼠尾静脉注射40 mg／kg的2-ME纳米混悬剂，对照组同法给予2-ME溶液。给药5、15、30、60、120、240、480 min后处死小鼠，取心、肝、脾、肺、肾、胃、脑及瘤组织，HPLC法测定血浆及上述组织中药物的质量浓度，计算总靶向效率和相对摄取率。结果：与对照组相比，实验组瘤体的总靶向效率由4．26％提高至15．20％，肺组织的总靶向效率由22．24％提高至50．32％；心、肝、脾、肺、脑、瘤组织的相对摄取率均大于1，瘤组织的相对摄取率最大。结论：制备的2-ME纳米混悬剂具有良好的瘤、肺靶向性。
목적：고찰2-갑양기자이순（2-ME）납미혼현제재폐암하류소서체내조직적분포특정。방법：70지곤명소서제작Lewis폐암하류서모형후수궤분위2조，실험조소서미정맥주사40 mg／kg적2-ME납미혼현제，대조조동법급여2-ME용액。급약5、15、30、60、120、240、480 min후처사소서，취심、간、비、폐、신、위、뇌급류조직，HPLC법측정혈장급상술조직중약물적질량농도，계산총파향효솔화상대섭취솔。결과：여대조조상비，실험조류체적총파향효솔유4．26％제고지15．20％，폐조직적총파향효솔유22．24％제고지50．32％；심、간、비、폐、뇌、류조직적상대섭취솔균대우1，류조직적상대섭취솔최대。결론：제비적2-ME납미혼현제구유량호적류、폐파향성。
Aim:To investigate tissue distribution character of 2-methoxyestradiol ( 2-ME ) nanosuspension in mice bearing Lewis cell line .Methods:Seventy Kunming mice were set up Lewis lung cancer model and randomly allocated into two groups .2-ME nanosuspension at 40 mg/kg or 2-ME solution were administered through tail vein of rats .Blood and tis-sue samples were obtained at 5,15,30,60,120,240 and 480 min after the administration and the concentrations of 2-ME in the above samples were determined ,and the targeting performance of 2-ME nanosuspension was evaluated .Results:Com-pared with control group ,the overall targeting efficiency of the experimental group improved from 4.26% to 15.20% in tumor tissue,and improved from 22.24%to 50.32%in lung tissue.Re of 2-ME nanosuspension for the heart ,liver,lung, spleen,brain,and tumor tissue was all above 1,among which,re for tumor tissue was the highest.Conclusion:2-ME nano-suspension has tissue targeting efficiency in tumor and lung .