CAJ | 학술논문

目的：研究半乳糖凝集素-3（Galectin-3）与基质金属蛋白酶-2（MMP-2）、组织基质金属蛋白酶抑制剂-2（TIMP-2）在大肠癌中的表达，并探讨其在大肠癌进展过程中的意义。方法应用免疫组化法检测52例大肠癌组织、20例大肠腺瘤和20例大肠正常黏膜组织中Galectin-3与MMP-2、TIMP-2的表达情况。结果①Galectin-3、MMP-2在大肠癌中的阳性表达率最高，而TIMP-2在大肠癌中的阳性表达率最低；②大肠癌组织中，浸润程度深、低分化及有淋巴结转移的Galectin-3、MMP-2的表达明显升高，而TIMP-2的表达则明显降低；③在大肠癌组织中Galectin-3与MMP-2的表达呈正相关，而与TIMP-2的表达呈负相关。结论 Galectin-3、MMP-2与TIMP-2表达的失平衡与大肠癌的浸润和转移密切相关。
목적：연구반유당응집소-3（Galectin-3）여기질금속단백매-2（MMP-2）、조직기질금속단백매억제제-2（TIMP-2）재대장암중적표체，병탐토기재대장암진전과정중적의의。방법응용면역조화법검측52례대장암조직、20례대장선류화20례대장정상점막조직중Galectin-3여MMP-2、TIMP-2적표체정황。결과①Galectin-3、MMP-2재대장암중적양성표체솔최고，이TIMP-2재대장암중적양성표체솔최저；②대장암조직중，침윤정도심、저분화급유림파결전이적Galectin-3、MMP-2적표체명현승고，이TIMP-2적표체칙명현강저；③재대장암조직중Galectin-3여MMP-2적표체정정상관，이여TIMP-2적표체정부상관。결론 Galectin-3、MMP-2여TIMP-2표체적실평형여대장암적침윤화전이밀절상관。
ObjectiveTo study the expression of Galectin-3 and MMP-2, TIMP-2 in colorectal carcinoma, and to investigate its in colorectal cancer progression of meaning in the course.MethodTo detect the expression of Galectin-3 and MMP-2,TIMP-2 in 52 cases of colorectal cancer, 20 cases of colorectal adenoma and 20 cases of colorectal normal mucosa tissue through the application of immunohistochemistry. Analyzed the relationship between its expression with the patient’s sex, age, tumor location, tumor differentiation, inifltration and lymph node metastasi.Result ①In colorectal carcinoma, the expression of Galectin-3 and MMP-2 were highest and the expression of TIMP-2 was lowest;②In inifltration over the muscle layer of the colorectal carcinoma and in poorly differentiated colorectal carcinoma and in lymph node metastasis of colorectal cancer tissues, the expression of Galectin-3 and MMP-2 were higher and the expression of TIMP-2 was lower;③The expression of Galectin-3 and MMP-2 were positive correlation and the expression of Galectin-3 and TIMP-2 were negative correlation in colorectal carcinoma.ConclusionThe imbalance expression of Galectin-3, MMP-2 and TIMP-2 is positive corrrelated with the invasion and metastasis of colorectal carcinoma.