中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2014年
10期
126-128
,共3页
吕行%张进儒%宁鹏%赵强
呂行%張進儒%寧鵬%趙彊
려행%장진유%저붕%조강
紫杉醇%顺铂%热灌注化疗%胃癌恶性腹腔积液
紫杉醇%順鉑%熱灌註化療%胃癌噁性腹腔積液
자삼순%순박%열관주화료%위암악성복강적액
Paclitaxel%Cisplatin%Hot perfusion chemotherapy%Malignant ascites of gastric cancer
目的：探讨紫杉醇联合顺铂腹腔持续热灌注化疗对晚期胃癌患者恶性腹腔积液的临床疗效。方法将104例晚期胃癌患者随机分为两组，试验组54例，对照组50例，两组患者治疗第1天均静脉滴注紫杉醇75 mg/m2（21天方案），试验组患者排出腹腔积液后恒温腹腔持续性循环灌注顺铂（设定温度45℃），对照组患者排出腹腔积液后灌注顺铂。两组患者均每周治疗1次，3周为一疗程；治疗后3周、3个月和6个月分别检测两组患者血清癌胚抗原（CEA）浓度并观察恶性腹腔积液变化。结果试验组有效率为53.7%，对照组有效率为30.0%，两组间比较有显著差异（P＜0.05）；试验组患者血清CEA浓度在治疗3个月后明显下降，且两组比较有显著差异（P＜0.05）。结论紫杉醇联合顺铂腹腔持续热灌注化疗治疗晚期胃癌恶性腹腔积液疗效肯定，且血清CEA浓度明显下降。
目的：探討紫杉醇聯閤順鉑腹腔持續熱灌註化療對晚期胃癌患者噁性腹腔積液的臨床療效。方法將104例晚期胃癌患者隨機分為兩組，試驗組54例，對照組50例，兩組患者治療第1天均靜脈滴註紫杉醇75 mg/m2（21天方案），試驗組患者排齣腹腔積液後恆溫腹腔持續性循環灌註順鉑（設定溫度45℃），對照組患者排齣腹腔積液後灌註順鉑。兩組患者均每週治療1次，3週為一療程；治療後3週、3箇月和6箇月分彆檢測兩組患者血清癌胚抗原（CEA）濃度併觀察噁性腹腔積液變化。結果試驗組有效率為53.7%，對照組有效率為30.0%，兩組間比較有顯著差異（P＜0.05）；試驗組患者血清CEA濃度在治療3箇月後明顯下降，且兩組比較有顯著差異（P＜0.05）。結論紫杉醇聯閤順鉑腹腔持續熱灌註化療治療晚期胃癌噁性腹腔積液療效肯定，且血清CEA濃度明顯下降。
목적：탐토자삼순연합순박복강지속열관주화료대만기위암환자악성복강적액적림상료효。방법장104례만기위암환자수궤분위량조，시험조54례，대조조50례，량조환자치료제1천균정맥적주자삼순75 mg/m2（21천방안），시험조환자배출복강적액후항온복강지속성순배관주순박（설정온도45℃），대조조환자배출복강적액후관주순박。량조환자균매주치료1차，3주위일료정；치료후3주、3개월화6개월분별검측량조환자혈청암배항원（CEA）농도병관찰악성복강적액변화。결과시험조유효솔위53.7%，대조조유효솔위30.0%，량조간비교유현저차이（P＜0.05）；시험조환자혈청CEA농도재치료3개월후명현하강，차량조비교유현저차이（P＜0.05）。결론자삼순연합순박복강지속열관주화료치료만기위암악성복강적액료효긍정，차혈청CEA농도명현하강。
ObjectiveTo explore the clinical curative effect to malignant ascites for advanced gastric cancer patients by paclitaxel combined with cisplatin abdominal continuous hot perfusion chemotherapy.Method104 cases of advanced gastric cancer patients were randomly divided into two groups, treatment group of 54 cases and control group of 50 cases, two groups of patients were given intravenous drip docetaxel 75 mg/m2 for the ifrst day (21 days); treatment group was given constant abdominal persistent circulation perfusion of cisplatin (set temperature 45℃) after releasing ascites, and control group was given with perfusion of cisplatin after releasing ascites; two groups of patients were given for once a week, 3 weeks as a course of treatment; detected the serum CEA levels and observed changes in malignant ascites after treatment of 3 weeks, 3 months and 6 months respectively.ResultThe effective rate of treatment group was 53.7%, and control group was 30.0%, and the difference was signiifcant between two groups (P<0.05); the concentration of serum CEA in treatment group was decreased obviously in the treatment of 3 months and was statistically differente compared with control group (P<0.05).ConclusionIntraperitoneal hot perfusion chemotherapy in the treatment of advanced gastric cancer malignant ascites is effective, and serum CEA markedly reduced.
